Suivre
Joana Cristóvão
Joana Cristóvão
Faculdade de Ciências, Universidade de Lisboa
Adresse e-mail validée de fc.ul.pt
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Année
S100 proteins in Alzheimer’s disease
JS Cristóvão, CM Gomes
Frontiers in Neuroscience 13, 446874, 2019
1552019
Metals and neuronal metal binding proteins implicated in Alzheimer’s disease
JS Cristóvão, R Santos, CM Gomes
Oxidative medicine and cellular longevity 2016, 2016
1492016
The neuronal S100B protein is a calcium-tuned suppressor of amyloid-β aggregation
JS Cristóvão, VK Morris, I Cardoso, SS Leal, J Martínez, HM Botelho, ...
Science advances 4 (6), eaaq1702, 2018
652018
Aberrant zinc binding to immature conformers of metal-free copper–zinc superoxide dismutase triggers amorphous aggregation
SS Leal, JS Cristóvão, A Biesemeier, I Cardoso, CM Gomes
Metallomics 7 (2), 333-346, 2015
402015
Zinc binding to S100B affords regulation of trace metal homeostasis and excitotoxicity in the brain
S Hagmeyer, JS Cristóvão, JJE Mulvihill, TM Boeckers, CM Gomes, ...
Frontiers in molecular neuroscience 10, 456, 2018
372018
Zinc binding to tau influences aggregation kinetics and oligomer distribution
GG Moreira, JS Cristóvão, VM Torres, AP Carapeto, MS Rodrigues, ...
International Journal of Molecular Sciences 20 (23), 5979, 2019
322019
Distribution and relative abundance of S100 proteins in the brain of the APP23 Alzheimer’s disease model mice
S Hagmeyer, MA Romão, JS Cristóvão, A Vilella, CM Gomes, ...
Frontiers in neuroscience 13, 449573, 2019
302019
Glucosylpolyphenols as inhibitors of Aβ-induced Fyn kinase activation and tau phosphorylation: synthesis, membrane permeability, and exploratory target assessment within the …
AM De Matos, MT Blazquez-Sanchez, A Bento-Oliveira, RFM de Almeida, ...
Journal of medicinal chemistry 63 (20), 11663-11690, 2020
232020
Calcium binding to gatekeeper residues flanking aggregation-prone segments underlies non-fibrillar amyloid traits in superoxide dismutase 1 (SOD1)
SG Estácio, SS Leal, JS Cristóvão, PFN Faísca, CM Gomes
Biochimica et Biophysica Acta (BBA)-Proteins and Proteomics 1854 (2), 118-126, 2015
192015
The S100B alarmin is a dual-function chaperone suppressing amyloid-β oligomerization through combined zinc chelation and inhibition of protein aggregation
JS Cristóvão, AJ Figueira, AP Carapeto, MS Rodrigues, I Cardoso, ...
ACS Chemical Neuroscience 11 (17), 2753-2760, 2020
182020
Biophysical and spectroscopic methods for monitoring protein misfolding and amyloid aggregation
JS Cristóvão, BJ Henriques, CM Gomes
Protein Misfolding Diseases: Methods and Protocols, 3-18, 2019
182019
Microfluidic production of mRNA-loaded lipid nanoparticles for vaccine applications
C Lopes, J Cristóvão, V Silvério, PR Lino, P Fonte
Expert Opinion on Drug Delivery 19 (10), 1381-1395, 2022
172022
Dynamic interactions and Ca2+-binding modulate the holdase-type chaperone activity of S100B preventing tau aggregation and seeding
GG Moreira, FX Cantrelle, A Quezada, FS Carvalho, JS Cristóvão, ...
Nature communications 12 (1), 6292, 2021
172021
Synthesis and effects of flavonoid structure variation on amyloid-β aggregation
AM Matos, JS Cristovao, DV Yashunsky, NE Nifantiev, AS Viana, ...
Pure and Applied Chemistry 89 (9), 1305-1320, 2017
162017
S100 proteins in Alzheimer’s disease. Front Neurosci. 2019; 13: 463
JS Cristóvão, CM Gomes
92019
Cu 2+-binding to S100B triggers polymerization of disulfide cross-linked tetramers with enhanced chaperone activity against amyloid-β aggregation
JS Cristóvão, GG Moreira, FEP Rodrigues, AP Carapeto, MS Rodrigues, ...
Chemical Communications 57 (3), 379-382, 2021
82021
S100B dysregulation during brain development affects synaptic SHANK protein networks via alteration of zinc homeostasis
E Daini, S Hagmeyer, CA De Benedictis, JS Cristóvão, M Bodria, ...
Translational Psychiatry 11 (1), 562, 2021
72021
Targeting S100B with peptides encoding intrinsic aggregation-prone sequence segments
JS Cristovao, MA Romao, R Gallardo, J Schymkowitz, F Rousseau, ...
Molecules 26 (2), 440, 2021
72021
Small molecules present in the cerebrospinal fluid metabolome influence superoxide dismutase 1 aggregation
JS Cristóvão, SS Leal, I Cardoso, CM Gomes
International Journal of Molecular Sciences 14 (9), 19128-19145, 2013
52013
Metals and neuronal metal binding proteins implicated in Alzheimer’s disease. Oxid Med Cell Longev. 2016; 2016: 9812178
JS Cristóvão, R Santos, CM Gomes
5
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