Nicholas Thomas Hertz
Nicholas Thomas Hertz
Chief Science Officer
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Cited by
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A Raf-induced allosteric transition of KSR stimulates phosphorylation of MEK
DF Brennan, AC Dar, NT Hertz, WCH Chao, AL Burlingame, KM Shokat, ...
Nature 472 (7343), 366-369, 2011
Drugging MYCN through an allosteric transition in Aurora kinase A
WC Gustafson, JG Meyerowitz, EA Nekritz, J Chen, C Benes, E Charron, ...
Cancer cell 26 (3), 414-427, 2014
A neo-substrate that amplifies catalytic activity of parkinson’s-disease-related kinase PINK1
NT Hertz, A Berthet, ML Sos, KS Thorn, AL Burlingame, K Nakamura, ...
Cell 154 (4), 737-747, 2013
Chemical genetic identification of NDR1/2 kinase substrates AAK1 and Rabin8 Uncovers their roles in dendrite arborization and spine development
SK Ultanir, NT Hertz, G Li, WP Ge, AL Burlingame, SJ Pleasure, ...
Neuron 73 (6), 1127-1142, 2012
Identification of AMPK phosphorylation sites reveals a network of proteins involved in cell invasion and facilitates large-scale substrate prediction
BE Schaffer, RS Levin, NT Hertz, TJ Maures, ML Schoof, PE Hollstein, ...
Cell metabolism 22 (5), 907-921, 2015
CRISPR–Cas9 screens in human cells and primary neurons identify modifiers of C9ORF72 dipeptide-repeat-protein toxicity
NJ Kramer, MS Haney, DW Morgens, A Jovičić, J Couthouis, A Li, J Ousey, ...
Nature genetics 50 (4), 603-612, 2018
Axon degeneration gated by retrograde activation of somatic pro-apoptotic signaling
DJ Simon, J Pitts, NT Hertz, J Yang, Y Yamagishi, O Olsen, MT Mark, ...
Cell 164 (5), 1031-1045, 2016
WNK1-regulated inhibitory phosphorylation of the KCC2 cotransporter maintains the depolarizing action of GABA in immature neurons
P Friedel, KT Kahle, J Zhang, N Hertz, LI Pisella, E Buhler, F Schaller, ...
Science signaling 8 (383), ra65-ra65, 2015
Chemical genetic approach for kinase‐substrate mapping by covalent capture of thiophosphopeptides and analysis by mass spectrometry
NT Hertz, BT Wang, JJ Allen, C Zhang, AC Dar, AL Burlingame, ...
Current protocols in chemical biology 2 (1), 15-36, 2010
A Ras-like domain in the light intermediate chain bridges the dynein motor to a cargo-binding region
CM Schroeder, JML Ostrem, NT Hertz, RD Vale
Elife 3, e03351, 2014
Development of a chemical genetic approach for human aurora B kinase identifies novel substrates of the chromosomal passenger complex
RCC Hengeveld, NT Hertz, MJM Vromans, C Zhang, AL Burlingame, ...
Molecular & Cellular Proteomics 11 (5), 47-59, 2012
MST3 kinase phosphorylates TAO1/2 to enable Myosin Va function in promoting spine synapse development
SK Ultanir, S Yadav, NT Hertz, JA Oses-Prieto, S Claxton, AL Burlingame, ...
Neuron 84 (5), 968-982, 2014
Innate immunity kinase TAK1 phosphorylates Rab1 on a hotspot for posttranslational modifications by host and pathogen
RS Levin, NT Hertz, AL Burlingame, KM Shokat, S Mukherjee
Proceedings of the National Academy of Sciences 113 (33), E4776-E4783, 2016
Long-term oral kinetin does not protect against α-synuclein-induced neurodegeneration in rodent models of Parkinson's disease
AL Orr, FU Rutaganira, D de Roulet, EJ Huang, NT Hertz, KM Shokat, ...
Neurochemistry international 109, 106-116, 2017
N6-Furfuryladenine is protective in Huntington’s disease models by signaling huntingtin phosphorylation
LE Bowie, T Maiuri, M Alpaugh, M Gabriel, N Arbez, D Galleguillos, ...
Proceedings of the National Academy of Sciences 115 (30), E7081-E7090, 2018
Structural plasticity of actin-spectrin membrane skeleton and functional role of actin and spectrin in axon degeneration
G Wang, DJ Simon, Z Wu, DM Belsky, E Heller, MK O'Rourke, NT Hertz, ...
Elife 8, e38730, 2019
Secreted 3-isopropylmalate methyl ester signals invasive growth during amino acid starvation in Saccharomyces cerevisiae
DS Dumlao, N Hertz, S Clarke
Biochemistry 47 (2), 698-709, 2008
Neuronally Enriched RUFY3 Is Required for Caspase-Mediated Axon Degeneration
NT Hertz, EL Adams, RA Weber, RJ Shen, MK O’Rourke, DJ Simon, ...
Neuron 103 (3), 412-422. e4, 2019
Compositions and methods for treating neurodegenerative diseases and cardiomyopathy
NT Hertz, KM Shokat, R DeVita
US Patent App. 14/823,934, 2016
Defining the proteolytic landscape during enterovirus infection
M Saeed, S Kapell, NT Hertz, X Wu, K Bell, AW Ashbrook, MT Mark, ...
PLoS pathogens 16 (9), e1008927, 2020
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