| Enzyme-like proteins by computational design DN Bolon, SL Mayo Proceedings of the National Academy of Sciences 98 (25), 14274-14279, 2001 | 560 | 2001 |
| Sculpting the proteome with AAA+ proteases and disassembly machines RT Sauer, DN Bolon, BM Burton, RE Burton, JM Flynn, RA Grant, ... Cell 119 (1), 9-18, 2004 | 514 | 2004 |
| Experimental illumination of a fitness landscape RT Hietpas, JD Jensen, DNA Bolon Proceedings of the National Academy of Sciences 108 (19), 7896-7901, 2011 | 344 | 2011 |
| Analyses of the effects of all ubiquitin point mutants on yeast growth rate BP Roscoe, KM Thayer, KB Zeldovich, D Fushman, DNA Bolon Journal of molecular biology 425 (8), 1363-1377, 2013 | 233 | 2013 |
| De novo design of biocatalysts DN Bolon, CA Voigt, SL Mayo Current opinion in chemical biology 6 (2), 125-129, 2002 | 222 | 2002 |
| Asymmetric interactions of ATP with the AAA+ ClpX6 unfoldase: allosteric control of a protein machine GL Hersch, RE Burton, DN Bolon, TA Baker, RT Sauer Cell 121 (7), 1017-1027, 2005 | 201 | 2005 |
| Specificity versus stability in computational protein design DN Bolon, RA Grant, TA Baker, RT Sauer Proceedings of the National Academy of Sciences 102 (36), 12724-12729, 2005 | 168 | 2005 |
| Dimerization of Hsp90 is required for in vivo function N Wayne, DN Bolon Journal of Biological Chemistry 282 (48), 35386-35395, 2007 | 141 | 2007 |
| Influenza virus drug resistance: a time-sampled population genetics perspective M Foll, YP Poh, N Renzette, A Ferrer-Admetlla, C Bank, H Shim, ... PLoS genetics 10 (2), e1004185, 2014 | 139 | 2014 |
| A systematic survey of an intragenic epistatic landscape C Bank, RT Hietpas, JD Jensen, DNA Bolon Molecular biology and evolution 32 (1), 229-238, 2015 | 136 | 2015 |
| Shifting fitness landscapes in response to altered environments RT Hietpas, C Bank, JD Jensen, DNA Bolon Evolution 67 (12), 3512-3522, 2013 | 129 | 2013 |
| Flexible linkers leash the substrate binding domain of SspB to a peptide module that stabilizes delivery complexes with the AAA+ ClpXP protease DA Wah, I Levchenko, GE Rieckhof, DN Bolon, TA Baker, RT Sauer Molecular cell 12 (2), 355-363, 2003 | 119 | 2003 |
| Systematic mutant analyses elucidate general and client-specific aspects of Hsp90 function P Mishra, JM Flynn, TN Starr, DNA Bolon Cell reports 15 (3), 588-598, 2016 | 99 | 2016 |
| A Bayesian MCMC approach to assess the complete distribution of fitness effects of new mutations: uncovering the potential for adaptive walks in challenging environments C Bank, RT Hietpas, A Wong, DN Bolon, JD Jensen Genetics 196 (3), 841-852, 2014 | 99 | 2014 |
| Nucleotide-dependent substrate handoff from the SspB adaptor to the AAA+ ClpXP protease DN Bolon, RA Grant, TA Baker, RT Sauer Molecular cell 16 (3), 343-350, 2004 | 95 | 2004 |
| Latent effects of Hsp90 mutants revealed at reduced expression levels L Jiang, P Mishra, RT Hietpas, KB Zeldovich, DNA Bolon PLoS genetics 9 (6), e1003600, 2013 | 93 | 2013 |
| Fitness analyses of all possible point mutations for regions of genes in yeast R Hietpas, B Roscoe, L Jiang, DNA Bolon Nature protocols 7 (7), 1382-1396, 2012 | 92 | 2012 |
| Quantifying and understanding the fitness effects of protein mutations: Laboratory versus nature JI Boucher, DNA Bolon, DS Tawfik Protein Science 25 (7), 1219-1226, 2016 | 89 | 2016 |
| Pervasive contingency and entrenchment in a billion years of Hsp90 evolution TN Starr, JM Flynn, P Mishra, DNA Bolon, JW Thornton Proceedings of the National Academy of Sciences 115 (17), 4453-4458, 2018 | 88 | 2018 |
| Hsp90 and client protein maturation N Wayne, P Mishra, DN Bolon Molecular chaperones: methods and protocols, 33-44, 2011 | 82 | 2011 |
Celia A SchifferProfessor and Chair of Biochemistry and Molecular Biotechnology, U Mass Chan Medical SchoolVerified email at umassmed.edu
