Dimitrios Spiliotopoulos
Dimitrios Spiliotopoulos
Xenometrix AG
Verified email at xenometrix.ch
Title
Cited by
Cited by
Year
An optimized experimental strategy for efficient conversion of embryonic stem (ES)-derived mouse neural stem (NS) cells into a nearly homogeneous mature neuronal population
D Spiliotopoulos, D Goffredo, L Conti, F Di Febo, G Biella, M Toselli, ...
Neurobiology of disease 34 (2), 320-331, 2009
802009
Exploring PHD fingers and H3K4me0 interactions with molecular dynamics simulations and binding free energy calculations: AIRE-PHD1, a comparative study
D Spiliotopoulos, A Spitaleri, G Musco
PloS one 7 (10), e46902, 2012
692012
muma, An R package for metabolomics univariate and multivariate statistical analysis
E Gaude, F Chignola, D Spiliotopoulos, A Spitaleri, M Ghitti, ...
Current Metabolomics 1 (2), 180-189, 2013
652013
Discovery of CREBBP bromodomain inhibitors by high-throughput docking and hit optimization guided by molecular dynamics
M Xu, A Unzue, J Dong, D Spiliotopoulos, C Nevado, A Caflisch
Journal of medicinal chemistry 59 (4), 1340-1349, 2016
602016
Discovery of BRD4 bromodomain inhibitors by fragment-based high-throughput docking
H Zhao, L Gartenmann, J Dong, D Spiliotopoulos, A Caflisch
Bioorganic & medicinal chemistry letters 24 (11), 2493-2496, 2014
572014
Fragment-based design of selective nanomolar ligands of the CREBBP bromodomain
A Unzue, M Xu, J Dong, L Wiedmer, D Spiliotopoulos, A Caflisch, ...
Journal of medicinal chemistry 59 (4), 1350-1356, 2016
442016
GMXPBSA 2.1: A GROMACS tool to perform MM/PBSA and computational alanine scanning.
C Paissoni, D Spiliotopoulos, G Musco, A Spitaleri
Comput. Phys. Commun. 186 (Supplement C), 105-107, 2015
432015
AIRE-PHD fingers are structural hubs to maintain the integrity of chromatin-associated interactome
M Gaetani, V Matafora, M Saare, D Spiliotopoulos, L Mollica, G Quilici, ...
Nucleic acids research 40 (22), 11756-11768, 2012
342012
dMM-PBSA: a new HADDOCK scoring function for protein-peptide docking
D Spiliotopoulos, PL Kastritis, ASJ Melquiond, AMJJ Bonvin, G Musco, ...
Frontiers in molecular biosciences 3, 46, 2016
322016
GMXPBSA 2.0: A GROMACS tool to perform MM/PBSA and computational alanine scanning
C Paissoni, D Spiliotopoulos, G Musco, A Spitaleri
Computer Physics Communications 185 (11), 2920-2929, 2014
282014
Chemical space expansion of bromodomain ligands guided by in silico virtual couplings (AutoCouple)
L Batiste, A Unzue, A Dolbois, F Hassler, X Wang, N Deerain, J Zhu, ...
ACS central science 4 (2), 180-188, 2018
162018
Discovery of BAZ2A bromodomain ligands
D Spiliotopoulos, EC Wamhoff, G Lolli, C Rademacher, A Caflisch
European journal of medicinal chemistry 139, 564-572, 2017
152017
Molecular dynamics simulations of bromodomains reveal binding‐site flexibility and multiple binding modes of the natural ligand acetyl‐lysine
D Spiliotopoulos, A Caflisch
Israel Journal of Chemistry 54 (8‐9), 1084-1092, 2014
152014
Virtual screen to NMR (VS2NMR): Discovery of fragment hits for the CBP bromodomain
D Spiliotopoulos, J Zhu, EC Wamhoff, N Deerain, JR Marchand, J Aretz, ...
Bioorganic & Medicinal Chemistry Letters 27 (11), 2472-2478, 2017
132017
Structural Analysis of the Binding of Type I, I1/2, and II Inhibitors to Eph Tyrosine Kinases
J Dong, H Zhao, T Zhou, D Spiliotopoulos, C Rajendran, XD Li, D Huang, ...
ACS medicinal chemistry letters 6 (1), 79-83, 2015
122015
Fragment-based in silico screening of bromodomain ligands
D Spiliotopoulos, A Caflisch
Drug Discovery Today: Technologies 19, 81-90, 2016
102016
Muma: Metabolomics Univariate and Multivariate Analysis
E Gaude, F Chignola, D Spiliotopoulos, S Mari, A Spitaleri, M Ghitti
R package version 1, 2012
92012
Identification of a novel de novo deletion in RAF1 associated with biventricular hypertrophy in Noonan syndrome
ME Sana, A Spitaleri, D Spiliotopoulos, L Pezzoli, L Preda, G Musco, ...
American Journal of Medical Genetics Part A 164 (8), 2069-2073, 2014
82014
A DNA transposon-based approach to functional screening in neural stem cells
I Albieri, M Onorati, G Calabrese, A Moiana, D Biasci, A Badaloni, ...
Journal of biotechnology 150 (1), 11-21, 2010
82010
Structural basis for PHDVC5HCHNSD1–C2HRNizp1 interaction: implications for Sotos syndrome
A Berardi, G Quilici, D Spiliotopoulos, MA Corral-Rodriguez, ...
Nucleic acids research 44 (7), 3448-3463, 2016
42016
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