Luigi Naldini
Luigi Naldini
Director, SR-TIGET, San Raffaele Telethon Institute for Gene Therapy, Professor of Tissue Biology
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In vivo gene delivery and stable transduction of nondividing cells by a lentiviral vector
L Naldini, U Blmer, P Gallay, D Ory, R Mulligan, FH Gage, IM Verma, ...
Science 272 (5259), 263-267, 1996
A third-generation lentivirus vector with a conditional packaging system
T Dull, R Zufferey, M Kelly, RJ Mandel, M Nguyen, D Trono, L Naldini
Journal of virology 72 (11), 8463-8471, 1998
Gene therapy-promises, problems and prospects
IM Verma, N Somia
Nature 389 (6648), 239-242, 1997
Multiply attenuated lentiviral vector achieves efficient gene delivery in vivo
R Zufferey, D Nagy, RJ Mandel, L Naldini, D Trono
Nature biotechnology 15 (9), 871-875, 1997
Self-inactivating lentivirus vector for safe and efficient in vivo gene delivery
R Zufferey, T Dull, RJ Mandel, A Bukovsky, D Quiroz, L Naldini, D Trono
Journal of virology 72 (12), 9873-9880, 1998
Efficient transfer, integration, and sustained long-term expression of the transgene in adult rat brains injected with a lentiviral vector.
L Naldini, U Blmer, FH Gage, D Trono, IM Verma
Proceedings of the National Academy of Sciences 93 (21), 11382-11388, 1996
Viral vectors for gene therapy: the art of turning infectious agents into vehicles of therapeutics
MA Kay, JC Glorioso, L Naldini
Nature medicine 7 (1), 33-40, 2001
Hepatocyte growth factor is a potent angiogenic factor which stimulates endothelial cell motility and growth.
F Bussolino, MF Di Renzo, M Ziche, E Bocchietto, M Olivero, L Naldini, ...
The Journal of cell biology 119 (3), 629-641, 1992
Gene transfer by lentiviral vectors is limited by nuclear translocation and rescued by HIV-1 pol sequences
A Follenzi, LE Ailles, S Bakovic, M Geuna, L Naldini
Nature genetics 25 (2), 217-222, 2000
Tie2 identifies a hematopoietic lineage of proangiogenic monocytes required for tumor vessel formation and a mesenchymal population of pericyte progenitors
M De Palma, MA Venneri, R Galli, LS Sergi, LS Politi, M Sampaolesi, ...
Cancer cell 8 (3), 211-226, 2005
Lentiviral hematopoietic stem cell gene therapy benefits metachromatic leukodystrophy
A Biffi, E Montini, L Lorioli, M Cesani, F Fumagalli, T Plati, C Baldoli, ...
Science 341 (6148), 1233158, 2013
Gene therapy returns to centre stage
L Naldini
Nature 526 (7573), 351-360, 2015
Lentiviral hematopoietic stem cell gene therapy in patients with Wiskott-Aldrich syndrome
A Aiuti, L Biasco, S Scaramuzza, F Ferrua, MP Cicalese, C Baricordi, ...
Science 341 (6148), 1233151, 2013
Gene editing in human stem cells using zinc finger nucleases and integrase-defective lentiviral vector delivery
A Lombardo, P Genovese, CM Beausejour, S Colleoni, YL Lee, KA Kim, ...
Nature biotechnology 25 (11), 1298-1306, 2007
Highly efficient and sustained gene transfer in adult neurons with a lentivirus vector
U Blmer, L Naldini, T Kafri, D Trono, IM Verma, FH Gage
Journal of virology 71 (9), 6641-6649, 1997
Hepatocyte growth factor (HGF) stimulates the tyrosine kinase activity of the receptor encoded by the proto-oncogene c-MET.
L Naldini, E Vigna, RP Narsimhan, G Gaudino, R Zarnegar, ...
Oncogene 6 (4), 501-504, 1991
Hematopoietic stem cell gene transfer in a tumor-prone mouse model uncovers low genotoxicity of lentiviral vector integration
E Montini, D Cesana, M Schmidt, F Sanvito, M Ponzoni, C Bartholomae, ...
Nature biotechnology 24 (6), 687-696, 2006
Scatter factor and hepatocyte growth factor are indistinguishable ligands for the MET receptor.
L Naldini, KM Weidner, E Vigna, G Gaudino, A Bardelli, C Ponzetto, ...
The EMBO journal 10 (10), 2867-2878, 1991
Extracellular proteolytic cleavage by urokinase is required for activation of hepatocyte growth factor/scatter factor.
L Naldini, L Tamagnone, E Vigna, M Sachs, G Hartmann, W Birchmeier, ...
The EMBO journal 11 (13), 4825-4833, 1992
An unbiased genome-wide analysis of zinc-finger nuclease specificity
R Gabriel, A Lombardo, A Arens, JC Miller, P Genovese, C Kaeppel, ...
Nature biotechnology 29 (9), 816-823, 2011
Il sistema al momento non pu eseguire l'operazione. Riprova pi tardi.
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