| Reduced food intake and body weight in mice treated with fatty acid synthase inhibitors TM Loftus, DE Jaworsky, GL Frehywot, CA Townsend, GV Ronnett, ... Science 288 (5475), 2379-2381, 2000 | 1315 | 2000 |
| Predictive, structure-based model of amino acid recognition by nonribosomal peptide synthetase adenylation domains GL Challis, J Ravel, CA Townsend Chemistry & biology 7 (3), 211-224, 2000 | 1001 | 2000 |
| Synthesis and antitumor activity of an inhibitor of fatty acid synthase FP Kuhajda, ES Pizer, JN Li, NS Mani, GL Frehywot, CA Townsend Proceedings of the National Academy of Sciences 97 (7), 3450-3454, 2000 | 775 | 2000 |
| Malonyl-coenzyme-A is a potential mediator of cytotoxicity induced by fatty-acid synthase inhibition in human breast cancer cells and xenografts ES Pizer, J Thupari, WF Han, ML Pinn, FJ Chrest, GL Frehywot, ... Cancer research 60 (2), 213-218, 2000 | 515 | 2000 |
| Comprehensive natural products II: chemistry and biology L Mander, HW Liu Elsevier, 2010 | 357 | 2010 |
| Enzymology and molecular biology of aflatoxin biosynthesis RE Minto, CA Townsend Chemical reviews 97 (7), 2537-2556, 1997 | 357 | 1997 |
| Fatty acid synthase inhibition triggers apoptosis during S phase in human cancer cells W Zhou, PJ Simpson, JM McFadden, CA Townsend, SM Medghalchi, ... Cancer research 63 (21), 7330-7337, 2003 | 313 | 2003 |
| New insights into the formation of fungal aromatic polyketides JM Crawford, CA Townsend Nature Reviews Microbiology 8 (12), 879-889, 2010 | 255 | 2010 |
| Deconstruction of iterative multidomain polyketide synthase function JM Crawford, PM Thomas, JR Scheerer, AL Vagstad, NL Kelleher, ... Science 320 (5873), 243-246, 2008 | 251 | 2008 |
| Identification of a starter unit acyl-carrier protein transacylase domain in an iterative type I polyketide synthase JM Crawford, BCR Dancy, EA Hill, DW Udwary, CA Townsend Proceedings of the National Academy of Sciences 103 (45), 16728-16733, 2006 | 226 | 2006 |
| Structural basis for biosynthetic programming of fungal aromatic polyketide cyclization JM Crawford, TP Korman, JW Labonte, AL Vagstad, EA Hill, ... Nature 461 (7267), 1139-1143, 2009 | 214 | 2009 |
| An externally tunable bacterial band-pass filter T Sohka, RA Heins, RM Phelan, JM Greisler, CA Townsend, M Ostermeier Proceedings of the National Academy of Sciences 106 (25), 10135-10140, 2009 | 213 | 2009 |
| Circular dichroism and magnetic circular dichroism spectroscopic studies of the non-heme ferrous active site in clavaminate synthase and its interaction with α-ketoglutarate … EG Pavel, J Zhou, RW Busby, M Gunsior, CA Townsend, EI Solomon Journal of the American Chemical Society 120 (4), 743-753, 1998 | 210 | 1998 |
| Spectroscopic studies of substrate interactions with clavaminate synthase 2, a multifunctional α-KG-dependent non-heme iron enzyme: correlation with mechanisms and reactivities J Zhou, WL Kelly, BO Bachmann, M Gunsior, CA Townsend, EI Solomon Journal of the American Chemical Society 123 (30), 7388-7398, 2001 | 207 | 2001 |
| The architectures of iterative type I PKS and FAS DA Herbst, CA Townsend, T Maier Natural product reports 35 (10), 1046-1069, 2018 | 194 | 2018 |
| Fatty acid synthase inhibition activates AMP-activated protein kinase in SKOV3 human ovarian cancer cells W Zhou, WF Han, LE Landree, JN Thupari, ML Pinn, T Bililign, EK Kim, ... Cancer research 67 (7), 2964-2971, 2007 | 182 | 2007 |
| Purification and characterization of clavaminate synthase from Streptomyces clavuligerus: an unusual oxidative enzyme in natural product biosynthesis SP Salowe, EN Marsh, CA Townsend Biochemistry 29 (27), 6499-6508, 1990 | 181 | 1990 |
| Intrinsic evolutionary constraints on protease structure, enzyme acylation, and the identity of the catalytic triad AR Buller, CA Townsend Proceedings of the National Academy of Sciences 110 (8), E653-E661, 2013 | 175 | 2013 |
| Expression of FAS within hypothalamic neurons: a model for decreased food intake after C75 treatment EK Kim, I Miller, LE Landree, FF Borisy-Rudin, P Brown, T Tihan, ... American Journal of Physiology-Endocrinology and Metabolism 283 (5), E867-E879, 2002 | 162 | 2002 |
| A new class of antituberculosis agents PB Jones, NM Parrish, TA Houston, A Stapon, NP Bansal, JD Dick, ... Journal of medicinal chemistry 43 (17), 3304-3314, 2000 | 156 | 2000 |
