Craig A. Townsend
Craig A. Townsend
A. H. Corwin Professor of Chemistry, Johns Hopkins University
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Cited by
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Reduced food intake and body weight in mice treated with fatty acid synthase inhibitors
TM Loftus, DE Jaworsky, GL Frehywot, CA Townsend, GV Ronnett, ...
Science 288 (5475), 2379-2381, 2000
Predictive, structure-based model of amino acid recognition by nonribosomal peptide synthetase adenylation domains
GL Challis, J Ravel, CA Townsend
Chemistry & biology 7 (3), 211-224, 2000
Synthesis and antitumor activity of an inhibitor of fatty acid synthase
FP Kuhajda, ES Pizer, JN Li, NS Mani, GL Frehywot, CA Townsend
Proceedings of the National Academy of Sciences 97 (7), 3450-3454, 2000
Malonyl-coenzyme-A is a potential mediator of cytotoxicity induced by fatty-acid synthase inhibition in human breast cancer cells and xenografts
ES Pizer, J Thupari, WF Han, ML Pinn, FJ Chrest, GL Frehywot, ...
Cancer research 60 (2), 213-218, 2000
Comprehensive natural products II: chemistry and biology
L Mander, HW Liu
Elsevier, 2010
Enzymology and molecular biology of aflatoxin biosynthesis
RE Minto, CA Townsend
Chemical reviews 97 (7), 2537-2556, 1997
Fatty acid synthase inhibition triggers apoptosis during S phase in human cancer cells
W Zhou, PJ Simpson, JM McFadden, CA Townsend, SM Medghalchi, ...
Cancer research 63 (21), 7330-7337, 2003
New insights into the formation of fungal aromatic polyketides
JM Crawford, CA Townsend
Nature Reviews Microbiology 8 (12), 879-889, 2010
Deconstruction of iterative multidomain polyketide synthase function
JM Crawford, PM Thomas, JR Scheerer, AL Vagstad, NL Kelleher, ...
Science 320 (5873), 243-246, 2008
Identification of a starter unit acyl-carrier protein transacylase domain in an iterative type I polyketide synthase
JM Crawford, BCR Dancy, EA Hill, DW Udwary, CA Townsend
Proceedings of the National Academy of Sciences 103 (45), 16728-16733, 2006
Structural basis for biosynthetic programming of fungal aromatic polyketide cyclization
JM Crawford, TP Korman, JW Labonte, AL Vagstad, EA Hill, ...
Nature 461 (7267), 1139-1143, 2009
Spectroscopic studies of substrate interactions with clavaminate synthase 2, a multifunctional α-KG-dependent non-heme iron enzyme: correlation with mechanisms and reactivities
J Zhou, WL Kelly, BO Bachmann, M Gunsior, CA Townsend, EI Solomon
Journal of the American Chemical Society 123 (30), 7388-7398, 2001
Circular dichroism and magnetic circular dichroism spectroscopic studies of the non-heme ferrous active site in clavaminate synthase and its interaction with α-ketoglutarate …
EG Pavel, J Zhou, RW Busby, M Gunsior, CA Townsend, EI Solomon
Journal of the American Chemical Society 120 (4), 743-753, 1998
An externally tunable bacterial band-pass filter
T Sohka, RA Heins, RM Phelan, JM Greisler, CA Townsend, M Ostermeier
Proceedings of the National Academy of Sciences 106 (25), 10135-10140, 2009
Fatty acid synthase inhibition activates AMP-activated protein kinase in SKOV3 human ovarian cancer cells
W Zhou, WF Han, LE Landree, JN Thupari, ML Pinn, T Bililign, EK Kim, ...
Cancer research 67 (7), 2964-2971, 2007
Purification and characterization of clavaminate synthase from Streptomyces clavuligerus: an unusual oxidative enzyme in natural product biosynthesis
SP Salowe, EN Marsh, CA Townsend
Biochemistry 29 (27), 6499-6508, 1990
Intrinsic evolutionary constraints on protease structure, enzyme acylation, and the identity of the catalytic triad
AR Buller, CA Townsend
Proceedings of the National Academy of Sciences 110 (8), E653-E661, 2013
The architectures of iterative type I PKS and FAS
DA Herbst, CA Townsend, T Maier
Natural product reports 35 (10), 1046-1069, 2018
Expression of FAS within hypothalamic neurons: a model for decreased food intake after C75 treatment
EK Kim, I Miller, LE Landree, FF Borisy-Rudin, P Brown, T Tihan, ...
American Journal of Physiology-Endocrinology and Metabolism 283 (5), E867-E879, 2002
A new class of antituberculosis agents
PB Jones, NM Parrish, TA Houston, A Stapon, NP Bansal, JD Dick, ...
Journal of medicinal chemistry 43 (17), 3304-3314, 2000
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