Reproducibility of CRISPR-Cas9 methods for generation of conditional mouse alleles: a multi-center evaluation CB Gurumurthy, AR O’brien, RM Quadros, J Adams, P Alcaide, S Ayabe, ... Genome biology 20 (1), 1-14, 2019 | 87 | 2019 |
KLK5 and KLK7 ablation fully rescues lethality of Netherton syndrome-like phenotype P Kasparek, Z Ileninova, O Zbodakova, I Kanchev, O Benada, ... PLoS genetics 13 (1), e1006566, 2017 | 79 | 2017 |
A resource of targeted mutant mouse lines for 5,061 genes MC Birling, A Yoshiki, DJ Adams, S Ayabe, AL Beaudet, J Bottomley, ... Nature genetics 53 (4), 416-419, 2021 | 74 | 2021 |
Efficient gene targeting of the Rosa26 locus in mouse zygotes using TALE nucleases P Kasparek, M Krausova, R Haneckova, V Kriz, O Zbodakova, V Korinek, ... FEBS letters 588 (21), 3982-3988, 2014 | 69 | 2014 |
Intrinsically disordered proteins drive enamel formation via an evolutionarily conserved self-assembly motif T Wald, F Spoutil, A Osickova, M Prochazkova, O Benada, P Kasparek, ... Proceedings of the National Academy of Sciences 114 (9), E1641-E1650, 2017 | 55 | 2017 |
In vivo regulation of the A disintegrin and metalloproteinase 10 (ADAM10) by the tetraspanin 15 L Seipold, H Altmeppen, T Koudelka, A Tholey, P Kasparek, R Sedlacek, ... Cellular and molecular life sciences 75, 3251-3267, 2018 | 47 | 2018 |
CRISPR/Cas9 epigenome editing potential for rare imprinting diseases: a review LA Syding, P Nickl, P Kasparek, R Sedlacek Cells 9 (4), 993, 2020 | 44 | 2020 |
Novel ADNP syndrome mice reveal dramatic sex-specific peripheral gene expression with brain synaptic and tau pathologies G Karmon, S Sragovich, G Hacohen-Kleiman, I Ben-Horin-Hazak, ... Biological psychiatry 92 (1), 81-95, 2022 | 37 | 2022 |
Tetraspanin 3: A central endocytic membrane component regulating the expression of ADAM10, presenilin and the amyloid precursor protein L Seipold, M Damme, J Prox, B Rabe, P Kasparek, R Sedlacek, ... Biochimica et Biophysica Acta (BBA)-Molecular Cell Research 1864 (1), 217-230, 2017 | 35 | 2017 |
Bardet–Biedl Syndrome ciliopathy is linked to altered hematopoiesis and dysregulated self‐tolerance O Tsyklauri, V Niederlova, E Forsythe, A Prasai, A Drobek, P Kasparek, ... EMBO reports 22 (2), e50785, 2021 | 33 | 2021 |
CRMP 2 mediates Sema3F‐dependent axon pruning and dendritic spine remodeling J Ziak, R Weissova, K Jeřábková, M Janikova, R Maimon, T Petrasek, ... EMBO reports 21 (3), e48512, 2020 | 33 | 2020 |
MMP-19 deficiency causes aggravation of colitis due to defects in innate immune cell function R Brauer, J Tureckova, I Kanchev, M Khoylou, J Skarda, J Prochazka, ... Mucosal immunology 9 (4), 974-985, 2016 | 27 | 2016 |
Intronic determinants coordinate charme lncRNA nuclear activity through the interaction with MATR3 and PTBP1 F Desideri, A Cipriano, S Petrezselyova, G Buonaiuto, T Santini, ... Cell reports 33 (12), 2020 | 24 | 2020 |
A viable mouse model for Netherton syndrome based on mosaic inactivation of the Spink5 gene P Kasparek, Z Ileninova, R Haneckova, I Kanchev, I Jenickova, ... Biological Chemistry 397 (12), 1287-1292, 2016 | 18 | 2016 |
Truncated PPM1D impairs stem cell response to genotoxic stress and promotes growth of APC-deficient tumors in the mouse colon M Burocziova, K Burdova, AS Martinikova, P Kasparek, P Kleiblova, ... Cell Death & Disease 10 (11), 818, 2019 | 16 | 2019 |
CRL4-DCAF12 ubiquitin ligase controls MOV10 RNA helicase during spermatogenesis and T cell activation T Lidak, N Baloghova, V Korinek, R Sedlacek, J Balounova, P Kasparek, ... International Journal of Molecular Sciences 22 (10), 5394, 2021 | 15 | 2021 |
TALEN-Based HvMPK3 Knock-Out Attenuates Proteome and Root Hair Phenotypic Responses to flg22 in Barley T Takáč, P Křenek, G Komis, P Vadovič, M Ovečka, L Ohnoutková, ... Frontiers in Plant Science 12, 666229, 2021 | 13 | 2021 |
ADAM10 and ADAM17 regulate EGFR, c-Met and TNF RI signalling in liver regeneration and fibrosis O Zbodakova, K Chalupsky, L Sarnova, P Kasparek, M Jirouskova, ... Scientific Reports 11 (1), 11414, 2021 | 12 | 2021 |
The iRhom2/ADAM17 axis attenuates bacterial uptake by phagocytes in a cell autonomous manner A Seifert, J Wozniak, S Düsterhöft, P Kasparek, R Sedlacek, S Dreschers, ... International Journal of Molecular Sciences 21 (17), 5978, 2020 | 10 | 2020 |
The iRhom homology domain is indispensable for ADAM17-mediated TNFα and EGF receptor ligand release S Düsterhöft, S Kahveci-Türköz, J Wozniak, A Seifert, P Kasparek, H Ohm, ... Cellular and Molecular Life Sciences 78 (11), 5015-5040, 2021 | 9 | 2021 |