| Alpha-synuclein: Pathology, mitochondrial dysfunction and neuroinflammation in Parkinson’s disease EM Rocha, B De Miranda, LH Sanders Neurobiology of disease 109, 249-257, 2018 | 665 | 2018 |
| LRRK2 activation in idiopathic Parkinson’s disease R Di Maio, EK Hoffman, EM Rocha, MT Keeney, LH Sanders, ... Science translational medicine 10 (451), eaar5429, 2018 | 434 | 2018 |
| PCR based determination of mitochondrial DNA copy number in multiple species JP Rooney, IT Ryde, LH Sanders, EH Howlett, MD Colton, KE Germ, ... Mitochondrial Regulation: Methods and Protocols, 23-38, 2015 | 381 | 2015 |
| Oxidative damage to macromolecules in human Parkinson disease and the rotenone model LH Sanders, JT Greenamyre Free Radical Biology and Medicine 62, 111-120, 2013 | 380 | 2013 |
| LRRK2 mutations cause mitochondrial DNA damage in iPSC-derived neural cells from Parkinson's disease patients: reversal by gene correction LH Sanders, J Laganière, O Cooper, SK Mak, BJ Vu, YA Huang, ... Neurobiology of disease 62, 381-386, 2014 | 285 | 2014 |
| Mitochondrial DNA damage: molecular marker of vulnerable nigral neurons in Parkinson's disease LH Sanders, J McCoy, X Hu, PG Mastroberardino, BC Dickinson, ... Neurobiology of disease 70, 214-223, 2014 | 195 | 2014 |
| Extensive uptake of α-synuclein oligomers in astrocytes results in sustained intracellular deposits and mitochondrial damage V Lindström, G Gustafsson, LH Sanders, EH Howlett, J Sigvardson, ... Molecular and Cellular Neuroscience 82, 143-156, 2017 | 194 | 2017 |
| Age-related declines in α-Klotho drive progenitor cell mitochondrial dysfunction and impaired muscle regeneration A Sahu, H Mamiya, SN Shinde, A Cheikhi, LL Winter, NV Vo, D Stolz, ... Nature communications 9 (1), 4859, 2018 | 132 | 2018 |
| Synthetic alpha-synuclein fibrils cause mitochondrial impairment and selective dopamine neurodegeneration in part via iNOS-mediated nitric oxide production V Tapias, X Hu, KC Luk, LH Sanders, VM Lee, JT Greenamyre Cellular and Molecular Life Sciences 74, 2851-2874, 2017 | 117 | 2017 |
| DNA damage by oxidative stress: Measurement strategies for two genomes CP Gonzalez-Hunt, M Wadhwa, LH Sanders Current Opinion in Toxicology 7, 87-94, 2018 | 113 | 2018 |
| Role of Pseudomonas aeruginosa dinB-Encoded DNA Polymerase IV in Mutagenesis LH Sanders, A Rockel, H Lu, DJ Wozniak, MD Sutton Journal of bacteriology 188 (24), 8573-8585, 2006 | 97 | 2006 |
| RAD52 is required for RNA-templated recombination repair in post-mitotic neurons S Welty, Y Teng, Z Liang, W Zhao, LH Sanders, JT Greenamyre, ... Journal of Biological Chemistry 293 (4), 1353-1362, 2018 | 95 | 2018 |
| LRRK2 G2019S-induced mitochondrial DNA damage is LRRK2 kinase dependent and inhibition restores mtDNA integrity in Parkinson’s disease EH Howlett, N Jensen, F Belmonte, F Zafar, X Hu, J Kluss, B Schüle, ... Human molecular genetics 26 (22), 4340-4351, 2017 | 94 | 2017 |
| Single-cell redox imaging demonstrates a distinctive response of dopaminergic neurons to oxidative insults MP Horowitz, C Milanese, R Di Maio, X Hu, LM Montero, LH Sanders, ... Antioxidants & redox signaling 15 (4), 855-871, 2011 | 83 | 2011 |
| LC/MS analysis of cardiolipins in substantia nigra and plasma of rotenone-treated rats: implication for mitochondrial dysfunction in Parkinson's disease YY Tyurina, AM Polimova, E Maciel, VA Tyurin, VI Kapralova, DE Winnica, ... Free radical research 49 (5), 681-691, 2015 | 80 | 2015 |
| Autophagy protects against aminochrome-induced cell death in substantia nigra-derived cell line I Paris, P Munoz, S Huenchuguala, E Couve, LH Sanders, JT Greenamyre, ... Toxicological Sciences 121 (2), 376-388, 2011 | 71 | 2011 |
| Evidence for compartmentalized axonal mitochondrial biogenesis: mitochondrial DNA replication increases in distal axons as an early response to Parkinson's disease-relevant stress VS Van Laar, B Arnold, EH Howlett, MJ Calderon, CMS Croix, ... Journal of Neuroscience 38 (34), 7505-7515, 2018 | 55 | 2018 |
| Folding landscape of mutant huntingtin exon1: diffusible multimers, oligomers and fibrils, and no detectable monomer B Sahoo, I Arduini, KW Drombosky, R Kodali, LH Sanders, ... PloS one 11 (6), e0155747, 2016 | 54 | 2016 |
| Overexpression of VMAT-2 and DT-diaphorase protects substantia nigra-derived cells against aminochrome neurotoxicity P Muñoz, I Paris, LH Sanders, JT Greenamyre, J Segura-Aguilar Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease 1822 (7 …, 2012 | 54 | 2012 |
| Sliding clamp–DNA interactions are required for viability and contribute to DNA polymerase management in Escherichia coli JMH Heltzel, SKS Ponticelli, LH Sanders, JM Duzen, V Cody, J Pace, ... Journal of molecular biology 387 (1), 74-91, 2009 | 53 | 2009 |
J Timothy GreenamyreDirector, Pittsburgh Institute for Neurodegenerative Diseases, Professor & Vice-Chair of NeurologyVerified email at pitt.edu
