| PAXX, a paralog of XRCC4 and XLF, interacts with Ku to promote DNA double-strand break repair T Ochi, AN Blackford, J Coates, S Jhujh, S Mehmood, N Tamura, ... Science 347 (6218), 185-188, 2015 | 366 | 2015 |
| Different DNA end configurations dictate which NHEJ components are most important for joining efficiency HHY Chang, G Watanabe, CA Gerodimos, T Ochi, TL Blundell, ... Journal of Biological Chemistry 291 (47), 24377-24389, 2016 | 118 | 2016 |
| Non-homologous end-joining partners in a helical dance: structural studies of XLF-XRCC4 interactions W Qian, O Takashi, MV Dijana, VR Carol, YC Dimitri, LB Tom Biochemical Society Transactions 39 (5), 1387-1392, 2011 | 91 | 2011 |
| The spatial organization of non-homologous end joining: from bridging to end joining T Ochi, Q Wu, TL Blundell DNA repair 17, 98-109, 2014 | 89 | 2014 |
| Dissection of DNA double-strand-break repair using novel single-molecule forceps JL Wang, C Duboc, Q Wu, T Ochi, S Liang, SE Tsutakawa, SP Lees-Miller, ... Nature structural & molecular biology 25 (6), 482-487, 2018 | 85 | 2018 |
| Mutations in the NHEJ component XRCC4 cause primordial dwarfism JE Murray, M Van Der Burg, H IJspeert, P Carroll, Q Wu, T Ochi, A Leitch, ... The American Journal of Human Genetics 96 (3), 412-424, 2015 | 85 | 2015 |
| Structure of BRCA1-BRCT/Abraxas complex reveals phosphorylation-dependent BRCT dimerization at DNA damage sites Q Wu, A Paul, D Su, S Mehmood, TK Foo, T Ochi, EL Bunting, B Xia, ... Molecular cell 61 (3), 434-448, 2016 | 75 | 2016 |
| Structure of the catalytic region of DNA ligase IV in complex with an Artemis fragment sheds light on double-strand break repair T Ochi, X Gu, TL Blundell Structure 21 (4), 672-679, 2013 | 74 | 2013 |
| Structural Insights into the Role of Domain Flexibility in Human DNA Ligase IV T Ochi, Q Wu, DY Chirgadze, JG Grossmann, VM Bolanos-Garcia, ... Structure, 2012 | 50 | 2012 |
| Structural biology of DNA repair: spatial organisation of the multicomponent complexes of nonhomologous end joining T Ochi, BL Sibanda, Q Wu, DY Chirgadze, VM Bolanos-Garcia, ... Journal of nucleic acids 2010, 2010 | 46 | 2010 |
| Spatial and temporal organization of multi-protein assemblies: achieving sensitive control in information-rich cell-regulatory systems VM Bolanos-Garcia, Q Wu, T Ochi, DY Chirgadze, BL Sibanda, ... Philosophical Transactions of the Royal Society A: Mathematical, Physical …, 2012 | 33 | 2012 |
| Perspectives on protein crystallisation T Ochi, VM Bolanos-Garcia, V Stojanoff, A Moreno Progress in biophysics and molecular biology 101 (1), 56-63, 2009 | 25 | 2009 |
| Investigations into protein crystallization in the presence of a strong magnetic field S Surade, T Ochi, D Nietlispach, D Chirgadze, A Moreno Crystal growth & design 10 (2), 691-699, 2010 | 24 | 2010 |
| Understanding the structure and role of DNA-PK in NHEJ: How X-ray diffraction and cryo-EM contribute in complementary ways Q Wu, S Liang, T Ochi, DY Chirgadze, JT Huiskonen, TL Blundell Progress in Biophysics and Molecular Biology 147, 26-32, 2019 | 20 | 2019 |
| Protein-protein interactions: structures and druggability DB Ascher, HC Jubb, DEV Pires, T Ochi, A Higueruelo, TL Blundell Multifaceted roles of crystallography in modern drug discovery, 141-163, 2015 | 14 | 2015 |
| CCDC61/VFL3 is a paralog of SAS6 and promotes ciliary functions T Ochi, V Quarantotti, H Lin, J Jullien, IR e Silva, F Boselli, DD Barnabas, ... Structure 28 (6), 674-689. e11, 2020 | 13 | 2020 |
| Achieving selectivity in space and time with DNA double-strand-break response and repair: molecular stages and scaffolds come with strings attached S Liang, SR Esswein, T Ochi, Q Wu, DB Ascher, D Chirgadze, BL Sibanda, ... Structural Chemistry 28, 161-171, 2017 | 12 | 2017 |
| Catalytically inactive DNA ligase IV promotes DNA repair in living cells NJ Goff, M Brenière, CJ Buehl, AJ de Melo, H Huskova, T Ochi, ... Nucleic Acids Research 50 (19), 11058-11071, 2022 | 11 | 2022 |
| Proteomic profiling of centrosomes across multiple mammalian cell and tissue types by an affinity capture method S Carden, E Vitiello, IR e Silva, J Holder, V Quarantotti, K Kishore, ... Developmental Cell 58 (21), 2393-2410. e9, 2023 | 5 | 2023 |
| Plant PAXX has an XLF‐like function and stimulates DNA end joining by the Ku‐DNA ligase IV/XRCC4 complex H Khan, T Ochi The Plant Journal 116 (1), 58-68, 2023 | 3 | 2023 |
Tom L BlundellEmeritus Professor of Biochemistry, University of CambridgeAdresse e-mail validée de cam.ac.uk
