Sebastian Hiller
Sebastian Hiller
Professor for Structural Biology and Biophysics, Biozentrum, University Basel, Switzerland
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GSDMD membrane pore formation constitutes the mechanism of pyroptotic cell death
L Sborgi, S Rühl, E Mulvihill, J Pipercevic, R Heilig, H Stahlberg, ...
The EMBO Journal 35 (16), 1766-1778, 2016
Solution structure of the integral human membrane protein VDAC-1 in detergent micelles
S Hiller, RG Garces, TJ Malia, VY Orekhov, M Colombini, G Wagner
Science 321 (5893), 1206-1210, 2008
A new antibiotic selectively kills Gram-negative pathogens
Y Imai, KJ Meyer, A Iinishi, Q Favre-Godal, R Green, S Manuse, M Caboni, ...
Nature 576 (7787), 459-464, 2019
Germline NLRP1 Mutations Cause Skin Inflammatory and Cancer Susceptibility Syndromes via Inflammasome Activation
FL Zhong, O Mamaï, L Sborgi, L Boussofara, R Hopkins, K Robinson, ...
Cell 167 (1), 187-202. e17, 2016
ASC filament formation serves as a signal amplification mechanism for inflammasomes
MS Dick, L Sborgi, S Rühl, S Hiller, P Broz
Nature communications 7 (1), 11929, 2016
The Gasdermin‐D pore acts as a conduit for IL‐1β secretion in mice
R Heilig, MS Dick, L Sborgi, E Meunier, S Hiller, P Broz
European journal of immunology 48 (4), 584-592, 2018
Automated projection spectroscopy (APSY)
S Hiller, F Fiorito, K Wüthrich, G Wider
Proceedings of the National Academy of Sciences of the United States of …, 2005
Chimeric peptidomimetic antibiotics against Gram-negative bacteria
A Luther, M Urfer, M Zahn, M Müller, SY Wang, M Mondal, A Vitale, ...
Nature 576 (7787), 452-458, 2019
Mechanism of membrane pore formation by human gasdermin‐D
E Mulvihill, L Sborgi, SA Mari, M Pfreundschuh, S Hiller, DJ Müller
The EMBO journal 37 (14), e98321, 2018
Regulation of α-synuclein by chaperones in mammalian cells
BM Burmann, JA Gerez, I Matečko-Burmann, S Campioni, P Kumari, ...
Nature 577 (7788), 127-132, 2020
PDCD4 inhibits translation initiation by binding to eIF4A using both its MA3 domains
C Suzuki, RG Garces, KA Edmonds, S Hiller, SG Hyberts, A Marintchev, ...
Proceedings of the National Academy of Sciences 105 (9), 3274-3279, 2008
Structural and functional characterization of the integral membrane protein VDAC-1 in lipid bilayer nanodiscs
T Raschle, S Hiller, TY Yu, AJ Rice, T Walz, G Wagner
Journal of the American Chemical Society 131 (49), 17777-17779, 2009
Cyclic di-GMP acts as a cell cycle oscillator to drive chromosome replication
C Lori, S Ozaki, S Steiner, R Böhm, S Abel, BN Dubey, T Schirmer, ...
Nature 523 (7559), 236-239, 2015
A Proton‐Detected 4D Solid‐State NMR Experiment for Protein Structure Determination
M Huber, S Hiller, P Schanda, M Ernst, A Böckmann, R Verel, BH Meier
ChemPhysChem 12 (5), 915-918, 2011
Structure and assembly of the mouse ASC inflammasome by combined NMR spectroscopy and cryo-electron microscopy
L Sborgi, F Ravotti, VP Dandey, MS Dick, A Mazur, S Reckel, M Chami, ...
Proceedings of the National Academy of Sciences 112 (43), 13237-13242, 2015
NMR structure of the apoptosis-and inflammation-related NALP1 pyrin domain
S Hiller, A Kohl, F Fiorito, T Herrmann, G Wider, J Tschopp, MG Grütter, ...
Structure 11 (10), 1199-1205, 2003
HP1(Swi6) Mediates the Recognition and Destruction of Heterochromatic RNA Transcripts
C Keller, R Adaixo, R Stunnenberg, KJ Woolcock, S Hiller, M Bühler
Molecular Cell, 2012
Conformation and dynamics of the periplasmic membrane-protein–chaperone complexes OmpX–Skp and tOmpA–Skp
BM Burmann, C Wang, S Hiller
Nature Structural and Molecular Biology 20 (11), 1265, 2013
The antibiotic darobactin mimics a β-strand to inhibit outer membrane insertase
H Kaur, RP Jakob, JK Marzinek, R Green, Y Imai, JR Bolla, E Agustoni, ...
Nature 593 (7857), 125-129, 2021
The 3D structures of VDAC represent a native conformation
S Hiller, J Abramson, C Mannella, G Wagner, K Zeth
Trends in biochemical sciences 35 (9), 514-521, 2010
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