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David M. Sabatini
David M. Sabatini
Institute of Organic Chemistry and Biochemistry of the CAS
Adresse e-mail validée de uochb.cas.cz - Page d'accueil
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Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1
DJ Klionsky, AK Abdel-Aziz, S Abdelfatah, M Abdellatif, A Abdoli, S Abel, ...
autophagy 17 (1), 1-382, 2021
13221*2021
mTOR signaling in growth control and disease
M Laplante, DM Sabatini
cell 149 (2), 274-293, 2012
93482012
Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
DD Sarbassov, DA Guertin, SM Ali, DM Sabatini
Science 307 (5712), 1098-1101, 2005
83272005
mTOR signaling in growth, metabolism, and disease
RA Saxton, DM Sabatini
Cell 168 (6), 960-976, 2017
72182017
CellProfiler: image analysis software for identifying and quantifying cell phenotypes
AE Carpenter, TR Jones, MR Lamprecht, C Clarke, IH Kang, O Friman, ...
Genome biology 7, 1-11, 2006
55242006
mTOR: from growth signal integration to cancer, diabetes and ageing
R Zoncu, A Efeyan, DM Sabatini
Nature reviews Molecular cell biology 12 (1), 21-35, 2011
46932011
mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery
DH Kim, DD Sarbassov, SM Ali, JE King, RR Latek, ...
Cell 110 (2), 163-175, 2002
37202002
Defining the role of mTOR in cancer
DA Guertin, DM Sabatini
Cancer cell 12 (1), 9-22, 2007
35242007
Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton
DD Sarbassov, SM Ali, DH Kim, DA Guertin, RR Latek, ...
Current biology 14 (14), 1296-1302, 2004
34102004
Genetic screens in human cells using the CRISPR-Cas9 system
T Wang, JJ Wei, DM Sabatini, ES Lander
Science 343 (6166), 80-84, 2014
32862014
Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB
DD Sarbassov, SM Ali, S Sengupta, JH Sheen, PP Hsu, AF Bagley, ...
Molecular cell 22 (2), 159-168, 2006
32822006
Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1
DA Barbie, P Tamayo, JS Boehm, SY Kim, SE Moody, IF Dunn, ...
Nature 462 (7269), 108-112, 2009
31002009
The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1
Y Sancak, TR Peterson, YD Shaul, RA Lindquist, CC Thoreen, ...
Science 320 (5882), 1496-1501, 2008
30952008
Cancer cell metabolism: Warburg and beyond
PP Hsu, DM Sabatini
Cell 134 (5), 703-707, 2008
28812008
mTOR signaling at a glance
M Laplante, DM Sabatini
Journal of cell science 122 (20), 3589-3594, 2009
28212009
Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids
Y Sancak, L Bar-Peled, R Zoncu, AL Markhard, S Nada, DM Sabatini
Cell 141 (2), 290-303, 2010
26632010
An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1
CC Thoreen, SA Kang, JW Chang, Q Liu, J Zhang, Y Gao, LJ Reichling, ...
Journal of Biological Chemistry 284 (12), 8023-8032, 2009
20422009
A lentiviral RNAi library for human and mouse genes applied to an arrayed viral high-content screen
J Moffat, DA Grueneberg, X Yang, SY Kim, AM Kloepfer, G Hinkle, ...
Cell 124 (6), 1283-1298, 2006
20252006
Growing roles for the mTOR pathway
DD Sarbassov, SM Ali, DM Sabatini
Current opinion in cell biology 17 (6), 596-603, 2005
20162005
RAFT1: a mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs
DM Sabatini, H Erdjument-Bromage, M Lui, P Tempst, SH Snyder
Cell 78 (1), 35-43, 1994
19931994
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