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Marc Hoemberger
Marc Hoemberger
Treeline Biosciences
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Cited by
Cited by
Year
Evolutionary drivers of thermoadaptation in enzyme catalysis
V Nguyen, C Wilson, M Hoemberger, JB Stiller, RV Agafonov, S Kutter, ...
Science 355 (6322), 289-294, 2017
1892017
Using ancient protein kinases to unravel a modern cancer drug’s mechanism
C Wilson, RV Agafonov, M Hoemberger, S Kutter, A Zorba, J Halpin, ...
Science 347 (6224), 882-886, 2015
1832015
Predicting multiple conformations via sequence clustering and AlphaFold2
HK Wayment-Steele, A Ojoawo, R Otten, JM Apitz, W Pitsawong, ...
Nature 625 (7996), 832-839, 2024
482024
Cumulative mechanism of several major imatinib-resistant mutations in Abl kinase
M Hoemberger, W Pitsawong, D Kern
Proceedings of the National Academy of Sciences 117 (32), 19221-19227, 2020
362020
Allosteric modulation of a human protein kinase with monobodies
A Zorba, V Nguyen, A Koide, M Hoemberger, Y Zheng, S Kutter, C Kim, ...
Proceedings of the National Academy of Sciences 116 (28), 13937-13942, 2019
352019
Probing the transition state in enzyme catalysis by high-pressure NMR dynamics
JB Stiller, S Jordan Kerns, M Hoemberger, YJ Cho, R Otten, MF Hagan, ...
Nature catalysis 2 (8), 726-734, 2019
312019
Discovery and preclinical characterization of BIIB091, a reversible, selective BTK inhibitor for the treatment of multiple sclerosis
BT Hopkins, E Bame, B Bajrami, C Black, T Bohnert, C Boiselle, ...
Journal of Medicinal Chemistry 65 (2), 1206-1224, 2021
192021
From primordial clocks to circadian oscillators
W Pitsawong, RAP Pádua, T Grant, M Hoemberger, R Otten, N Bradshaw, ...
Nature 616 (7955), 183-189, 2023
102023
Optimization of a novel piperazinone series as potent selective peripheral covalent BTK inhibitors
B Ma, CM Metrick, C Gu, M Hoemberger, B Bajrami, E Bame, J Huang, ...
Bioorganic & Medicinal Chemistry Letters 60, 128549, 2022
52022
Probing an ancient protein's dynamics with NMR
MS Hoemberger, CG Wilson, D Kern
Biophysical journal 106 (2), 657a, 2014
32014
From primordial clocks to circadian oscillators
N Bradshaw, W Pitsawong, R Ap Pádua, T Grant, M Hoemberger, R Otten, ...
Nature, 2023
2023
Optimization of a novel piperazinone series as potent selective peripheral covalent BTK inhibitors (vol 60, 128549, 2022)
B Ma, CM Metrick, C Gu, M Hoemberger, B Bajrami, E Bame, J Huang, ...
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 72, 2022
2022
Natural evolution sheds light on modern drug resistance in protein kinases
M Hoemberger, C Wilson, R Agafonov, D Kern
PROTEIN SCIENCE 24, 310-310, 2015
2015
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