| Small-molecule ligands bind to a distinct pocket in Ras and inhibit SOS-mediated nucleotide exchange activity T Maurer, LS Garrenton, A Oh, K Pitts, DJ Anderson, NJ Skelton, ... Proceedings of the National Academy of Sciences 109 (14), 5299-5304, 2012 | 683 | 2012 |
| Phenotypic screening in cancer drug discovery—past, present and future JG Moffat, J Rudolph, D Bailey Nature reviews Drug discovery 13 (8), 588-602, 2014 | 543 | 2014 |
| Highly Efficient Epoxidation of Olefins Using Aqueous H2O2 and Catalytic Methyltrioxorhenium/Pyridine: Pyridine-Mediated Ligand Acceleration J Rudolph, KL Reddy, JP Chiang, KB Sharpless Journal of the American Chemical Society 119 (26), 6189-6190, 1997 | 536 | 1997 |
| Small-molecule ghrelin receptor antagonists improve glucose tolerance, suppress appetite, and promote weight loss WP Esler, J Rudolph, TH Claus, W Tang, N Barucci, SE Brown, W Bullock, ... Endocrinology 148 (11), 5175-5185, 2007 | 266 | 2007 |
| seco-Cyclothialidines: New Concise Synthesis, Inhibitory Activity toward Bacterial and Human DNA Topoisomerases, and Antibacterial Properties J Rudolph, H Theis, R Hanke, R Endermann, L Johannsen, FU Geschke Journal of medicinal chemistry 44 (4), 619-626, 2001 | 253 | 2001 |
| Quinazolinone derivatives as orally available ghrelin receptor antagonists for the treatment of diabetes and obesity J Rudolph, WP Esler, S O'connor, PDG Coish, PL Wickens, M Brands, ... Journal of medicinal chemistry 50 (21), 5202-5216, 2007 | 186 | 2007 |
| Smaller Substituents on Nitrogen Facilitate the Osmium‐Catalyzed Asymmetric Aminohydroxylation J Rudolph, PC Sennhenn, CP Vlaar, KB Sharpless Angewandte Chemie International Edition in English 35 (23‐24), 2810-2813, 1996 | 137 | 1996 |
| Inhibitors of p21-activated kinases (PAKs) miniperspective J Rudolph, JJ Crawford, KP Hoeflich, W Wang Journal of medicinal chemistry 58 (1), 111-129, 2015 | 125 | 2015 |
| Ras inhibition via direct Ras binding—is there a path forward? W Wang, G Fang, J Rudolph Bioorganic & medicinal chemistry letters 22 (18), 5766-5776, 2012 | 107 | 2012 |
| Highly efficient transport of amino acids through liquid membranes via three-component supramolecules MT Reetz, J Huff, J Rudolph, K Toellner, A Deege, R Goddard Journal of the American Chemical Society 116 (25), 11588-11589, 1994 | 107 | 1994 |
| Total synthesis of the nematicidal cyclododecapeptide omphalotin A by using racemization-free triphosgene-mediated couplings in the solid phase. B Thern, J Rudolph, G Jung | 105 | 2002 |
| P21-activated kinase 1 (PAK1) as a therapeutic target in BRAF wild-type melanoma CC Ong, AM Jubb, D Jakubiak, W Zhou, J Rudolph, PM Haverty, ... Journal of the National Cancer Institute 105 (9), 606-607, 2013 | 98 | 2013 |
| Triphosgene as highly efficient reagent for the solid-phase coupling of N-alkylated amino acids—total synthesis of cyclosporin O B Thern, J Rudolph, G Jung Tetrahedron letters 43 (28), 5013-5016, 2002 | 97 | 2002 |
| Disruption of IRE1α through its kinase domain attenuates multiple myeloma JM Harnoss, A Le Thomas, A Shemorry, SA Marsters, DA Lawrence, M Lu, ... Proceedings of the National Academy of Sciences 116 (33), 16420-16429, 2019 | 92 | 2019 |
| Design of Selective PAK1 Inhibitor G-5555: Improving Properties by Employing an Unorthodox Low-pKa Polar Moiety CO Ndubaku, JJ Crawford, J Drobnick, I Aliagas, D Campbell, P Dong, ... ACS medicinal chemistry letters 6 (12), 1241-1246, 2015 | 81 | 2015 |
| Indanylacetic Acid Derivatives Carrying 4-Thiazolyl-phenoxy Tail Groups, a New Class of Potent PPAR α/γ/δ Pan Agonists: Synthesis, Structure− Activity Relationship, and In Vivo … J Rudolph, L Chen, D Majumdar, WH Bullock, M Burns, T Claus, ... Journal of medicinal chemistry 50 (5), 984-1000, 2007 | 79 | 2007 |
| 3, 3′-dinitro-octahydrobinaphthol: A new chiral ligand for metal-catalyzed enantioselective reactions MT Reetz, C Merk, G Naberfeld, J Rudolph, N Griebenow, R Goddard Tetrahedron letters 38 (30), 5273-5276, 1997 | 76 | 1997 |
| Pharmacological induction of RAS-GTP confers RAF inhibitor sensitivity in KRAS mutant tumors I Yen, F Shanahan, M Merchant, C Orr, T Hunsaker, M Durk, H La, ... Cancer Cell 34 (4), 611-625. e7, 2018 | 75 | 2018 |
| Small molecule inhibition of group I p21-activated kinases in breast cancer induces apoptosis and potentiates the activity of microtubule stabilizing agents CC Ong, S Gierke, C Pitt, M Sagolla, CK Cheng, W Zhou, AM Jubb, ... Breast Cancer Research 17, 1-12, 2015 | 70 | 2015 |
| Pyrazolopyridine inhibitors of B-RafV600E. Part 2: Structure–activity relationships S Wenglowsky, KA Ahrendt, AJ Buckmelter, B Feng, SL Gloor, S Gradl, ... Bioorganic & medicinal chemistry letters 21 (18), 5533-5537, 2011 | 68 | 2011 |
