| HMG-CoA reductase inhibitors and the malignant cell: the statin family of drugs as triggers of tumor-specific apoptosis WWL Wong, J Dimitroulakos, MD Minden, LZ Penn Leukemia 16 (4), 508-519, 2002 | 702 | 2002 |
| Increased sensitivity of acute myeloid leukemias to lovastatin-induced apoptosis: a potential therapeutic approach J Dimitroulakos, D Nohynek, KL Backway, DW Hedley, H Yeger, ... Blood, The Journal of the American Society of Hematology 93 (4), 1308-1318, 1999 | 282 | 1999 |
| Blocking protein geranylgeranylation is essential for lovastatin-induced apoptosis of human acute myeloid leukemia cells Z Xia, MM Tan, W Wei-Lynn Wong, J Dimitroulakos, MD Minden, LZ Penn Leukemia 15 (9), 1398-1407, 2001 | 253 | 2001 |
| Differential sensitivity of various pediatric cancers and squamous cell carcinomas to lovastatin-induced apoptosis: therapeutic implications J Dimitroulakos, LY Ye, M Benzaquen, MJ Moore, S Kamel-Reid, ... Clinical cancer research 7 (1), 158-167, 2001 | 214 | 2001 |
| Cerivastatin triggers tumor-specific apoptosis with higher efficacy than lovastatin WWL Wong, MM Tan, Z Xia, J Dimitroulakos, MD Minden, LZ Penn Clinical cancer research 7 (7), 2067-2075, 2001 | 177 | 2001 |
| Stage-dependent differential expression of microRNAs in colorectal cancer: potential role as markers of metastatic disease MM Vickers, J Bar, I Gorn-Hondermann, N Yarom, M Daneshmand, ... Clinical & experimental metastasis 29, 123-132, 2012 | 152 | 2012 |
| HMG–CoA reductase mediates the biological effects of retinoic acid on human neuroblastoma cells: Lovastatin specifically targets P–glycoprotein–expressing cells J Dimitroulakos, H Yeger Nature medicine 2 (3), 326-333, 1996 | 137 | 1996 |
| A Phase I trial of prolonged administration of lovastatin in patients with recurrent or metastatic squamous cell carcinoma of the head and neck or of the cervix JJ Knox, LL Siu, E Chen, J Dimitroulakos, S Kamel-Reid, MJ Moore, ... European journal of cancer 41 (4), 523-530, 2005 | 129 | 2005 |
| Lovastatin induces a pronounced differentiation response in acute myeloid leukemias J Dimitroulakos, S Thai, GH Wasfy, DW Hedley, MD Minden, LZ Penn Leukemia & lymphoma 40 (1-2), 167-178, 2000 | 127 | 2000 |
| Targeting the mevalonate pathway inhibits the function of the epidermal growth factor receptor AJ Mantha, JEL Hanson, G Goss, AE Lagarde, IA Lorimer, J Dimitroulakos Clinical cancer research 11 (6), 2398-2407, 2005 | 125 | 2005 |
| MYCN protein expression as a predictor of neuroblastoma prognosis. HS Chan, BL Gallie, G DeBoer, G Haddad, N Ikegaki, J Dimitroulakos, ... Clinical cancer research: an official journal of the American Association …, 1997 | 124 | 1997 |
| Microarray and biochemical analysis of lovastatin-induced apoptosis of squamous cell carcinomas J Dimitroulakos, WH Marhin, J Tokunaga, J Irish, P Gullane, LZ Penn, ... Neoplasia 4 (4), 337-346, 2002 | 120 | 2002 |
| The DNA repair proteins BRCA1 and ERCC1 as predictive markers in sporadic ovarian cancer J Weberpals, K Garbuio, A O'Brien, K Clark‐Knowles, S Doucette, ... International Journal of Cancer 124 (4), 806-815, 2009 | 113 | 2009 |
| Lovastatin-induced apoptosis of human medulloblastoma cell lines in vitro RJB Macaulay, W Wang, J Dimitroulakos, LE Becker, H Yeger Journal of neuro-oncology 42, 1-11, 1999 | 108 | 1999 |
| Cisplatin induces cytotoxicity through the mitogen-activated protein kinase pathways ana activating transcription factor 3 CS Germain, N Niknejad, L Ma, K Garbuio, T Hai, J Dimitroulakos Neoplasia 12 (7), 527-538, 2010 | 106 | 2010 |
| Lovastatin enhances gefitinib activity in glioblastoma cells irrespective of EGFRvIII and PTEN status C Cemeus, TT Zhao, GM Barrett, IA Lorimer, J Dimitroulakos Journal of neuro-oncology 90, 9-17, 2008 | 86 | 2008 |
| Lovastatin induced control of blast cell growth in an elderly patient with acute myeloblastic leukemia MD Minden, J Dimitroulakos, D Nohynek, LZ Penn Leukemia & lymphoma 40 (5-6), 659-662, 2001 | 81 | 2001 |
| Lovastatin inhibits EGFR dimerization and AKT activation in squamous cell carcinoma cells: potential regulation by targeting rho proteins TT Zhao, BG Le Francois, G Goss, K Ding, PA Bradbury, J Dimitroulakos Oncogene 29 (33), 4682-4692, 2010 | 76 | 2010 |
| Dual inhibition of Wnt and Yes‐associated protein signaling retards the growth of triple‐negative breast cancer in both mesenchymal and epithelial states A Sulaiman, S McGarry, L Li, D Jia, S Ooi, C Addison, J Dimitroulakos, ... Molecular oncology 12 (4), 423-440, 2018 | 66 | 2018 |
| Strategies to enhance epidermal growth factor inhibition: targeting the mevalonate pathway J Dimitroulakos, IA Lorimer, G Goss Clinical Cancer Research 12 (14), 4426s-4431s, 2006 | 64 | 2006 |
Linda Z. PennSenior Scientist, Princess Margaret Cancer Centre, Toronto, Ontario CanadaVerified email at uhnresearch.ca
