| Rings in drugs: Miniperspective RD Taylor, M MacCoss, ADG Lawson Journal of medicinal chemistry 57 (14), 5845-5859, 2014 | 2034 | 2014 |
| Chimeric receptors providing both primary and costimulatory signaling in T cells from a single gene product HM Finney, ADG Lawson, CR Bebbington, ANC Weir The Journal of Immunology 161 (6), 2791-2797, 1998 | 638 | 1998 |
| Activation of resting human primary T cells with chimeric receptors: costimulation from CD28, inducible costimulator, CD134, and CD137 in series with signals from the TCRζ chain HM Finney, AN Akbar, ADG Lawson The Journal of Immunology 172 (1), 104-113, 2004 | 629 | 2004 |
| A single amino acid substitution abolishes the heterogeneity of chimeric mouse/human (IgG4) antibody S Angal, DJ King, MW Bodmer, A Turner, ADG Lawson, G Roberts, ... Molecular immunology 30 (1), 105-108, 1993 | 462 | 1993 |
| The loss of telomerase activity in highly differentiated CD8+ CD28− CD27− T cells is associated with decreased Akt (Ser473) phosphorylation FJ Plunkett, O Franzese, HM Finney, JM Fletcher, LL Belaramani, ... The Journal of Immunology 178 (12), 7710-7719, 2007 | 251 | 2007 |
| Dual IL-17A and IL-17F neutralisation by bimekizumab in psoriatic arthritis: evidence from preclinical experiments and a randomised placebo-controlled clinical trial that IL … S Glatt, D Baeten, T Baker, M Griffiths, L Ionescu, ADG Lawson, A Maroof, ... Annals of the rheumatic diseases 77 (4), 523-532, 2018 | 233 | 2018 |
| Multimerization behaviour of single chain Fv variants for the tumour-binding antibody B72. 3 D Desplancq, DJ King, ADG Lawson, A Mountain Protein Engineering, Design and Selection 7 (8), 1027-1033, 1994 | 210 | 1994 |
| Improved tumor targeting with chemically cross-linked recombinant antibody fragments DJ King, A Turner, APH Farnsworth, JR Adair, RJ Owens, RB Pedley, ... Cancer research 54 (23), 6176-6185, 1994 | 163 | 1994 |
| Sclerostin-binding antibody C Paszty, MK Robinson, K Graham, AJ Henry, KS Hoffmann, J Latham, ... US Patent 7,592,429, 2009 | 158 | 2009 |
| Cytokine-induced killer cells for cell therapy of acute myeloid leukemia: improvement of their immune activity by expression of CD33-specific chimeric receptors V Marin, I Pizzitola, V Agostoni, GMPG Attianese, H Finney, A Lawson, ... Haematologica 95 (12), 2144, 2010 | 157 | 2010 |
| Prolonged in vivo residence times of antibody fragments associated with albumin BJ Smith, A Popplewell, D Athwal, AP Chapman, S Heywood, SM West, ... Bioconjugate chemistry 12 (5), 750-756, 2001 | 157 | 2001 |
| Rings in clinical trials and drugs: present and future J Shearer, JL Castro, ADG Lawson, M MacCoss, RD Taylor Journal of Medicinal Chemistry 65 (13), 8699-8712, 2022 | 130 | 2022 |
| Synthetic transmembrane components ADG Lawson, HM Finney US Patent 7,052,906, 2006 | 130 | 2006 |
| Artificial T-cell receptors M Pule, H Finney, A Lawson Cytotherapy 5 (3), 211-226, 2003 | 128 | 2003 |
| In vitro and in vivo antitumor effect of anti-cd33 chimeric receptor-expressing EBV-CTL against acute myeloid leukemia A Dutour, V Marin, I Pizzitola, S Valsesia-Wittmann, D Lee, E Yvon, ... Advances in hematology 2012, 2012 | 121 | 2012 |
| Chimeric cytoplasmic signalling molecules derived from CD137 HM Finney, ADG Lawson | 120 | 2002 |
| Formatting antibody fragments to mediate specific therapeutic functions ANC Weir, A Nesbitt, AP Chapman, AGPP Antoniw, ADG Lawson Biochemical Society Transactions 30 (4), 512-516, 2002 | 116 | 2002 |
| Immunoassays for the Detection of Human Collagenase, Stromelysin, Tissue Inhibitor of Metallo-proteinases (TIMP) and Enzyme-Inhibitor Complexes S Cooksley, JB Hipkiss, SP Tickle, E Holmes-Ievers, AJP Docherty, ... Matrix 10 (5), 285-291, 1990 | 112 | 1990 |
| Preparation and preclinical evaluation of humanised A33 immunoconjugates for radioimmunotherapy DJ King, P Antoniw, RJ Owens, JR Adair, AMR Haines, APH Farnsworth, ... British journal of cancer 72 (6), 1364-1372, 1995 | 110 | 1995 |
| Importance of rigidity in designing small molecule drugs to tackle protein–protein interactions (PPIs) through stabilization of desired conformers: miniperspective ADG Lawson, M MacCoss, JP Heer Journal of Medicinal Chemistry 61 (10), 4283-4289, 2017 | 108 | 2017 |
Richard D TaylorDirector, CADD, UCBVerified email at ucb.com
Richard D TaylorDirector, CADD, UCBVerified email at ucb.com