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Chetan Sukuru
Chetan Sukuru
Director, Research Informatics, Tango
Verified email at tangotx.com - Homepage
Title
Cited by
Cited by
Year
How similar are similarity searching methods? A principal component analysis of molecular descriptor space
A Bender, JL Jenkins, J Scheiber, SCK Sukuru, M Glick, JW Davies
Journal of chemical information and modeling 49 (1), 108-119, 2009
3092009
Mapping adverse drug reactions in chemical space
J Scheiber, JL Jenkins, SCK Sukuru, A Bender, D Mikhailov, M Milik, ...
Journal of medicinal chemistry 52 (9), 3103-3107, 2009
1852009
Gaining insight into off-target mediated effects of drug candidates with a comprehensive systems chemical biology analysis
J Scheiber, B Chen, M Milik, SCK Sukuru, A Bender, D Mikhailov, ...
Journal of chemical information and modeling 49 (2), 308-317, 2009
1772009
PALI—a database of Phylogeny and ALIgnment of homologous protein structures
S Balaji, S Sujatha, SSC Kumar, N Srinivasan
Nucleic Acids Research 29 (1), 61-65, 2001
1192001
Discovery of cytotoxic dolastatin 10 analogues with N-terminal modifications
A Maderna, M Doroski, C Subramanyam, A Porte, CA Leverett, ...
Journal of medicinal chemistry 57 (24), 10527-10543, 2014
1162014
Plate-based diversity selection based on empirical HTS data to enhance the number of hits and their chemical diversity
SCK Sukuru, JL Jenkins, REJ Beckwith, J Scheiber, A Bender, ...
SLAS Discovery 14 (6), 690-699, 2009
862009
Optimization of tubulysin antibody–drug conjugates: a case study in addressing ADC metabolism
LN Tumey, CA Leverett, B Vetelino, F Li, B Rago, X Han, F Loganzo, ...
ACS medicinal chemistry letters 7 (11), 977-982, 2016
602016
Discovering new classes of Brugia malayi asparaginyl-tRNA synthetase inhibitors and relating specificity to conformational change
SCK Sukuru, T Crepin, Y Milev, LC Marsh, JB Hill, RJ Anderson, ...
Journal of computer-aided molecular design 20 (3), 159-178, 2006
502006
The structure of urease activation complexes examined by flexibility analysis, mutagenesis, and small-angle X-ray scattering
S Quiroz-Valenzuela, SCK Sukuru, RP Hausinger, LA Kuhn, WT Heller
Archives of biochemistry and biophysics 480 (1), 51-57, 2008
442008
“Virtual fragment linking”: an approach to identify potent binders from low affinity fragment hits
TJ Crisman, A Bender, M Milik, JL Jenkins, J Scheiber, SCK Sukuru, ...
Journal of medicinal chemistry 51 (8), 2481-2491, 2008
432008
Design, synthesis, and cytotoxic evaluation of novel tubulysin analogues as ADC payloads
CA Leverett, SCK Sukuru, BC Vetelino, S Musto, K Parris, J Pandit, ...
ACS medicinal chemistry letters 7 (11), 999-1004, 2016
272016
New cytotoxic benzosuberene analogs. Synthesis, molecular modeling and biological evaluation
Z Chen, A Maderna, SCK Sukuru, M Wagenaar, CJ O’Donnell, MH Lam, ...
Bioorganic & medicinal chemistry letters 23 (24), 6688-6694, 2013
182013
A lead discovery strategy driven by a comprehensive analysis of proteases in the peptide substrate space
SCK Sukuru, F Nigsch, J Quancard, M Renatus, R Chopra, N Brooijmans, ...
Protein Science 19 (11), 2096-2109, 2010
92010
Discovery of new auristatins for the use on antibody drug conjugates for the treatment of cancer
A Maderna, M Doroski, H Risley, A Porte, Z Chen, C Subramanyam, ...
Abstracts of Papers of the American Chemical Society 246, 2013
22013
SPREAD—exploiting chemical features that cause differential activity behavior
J Scheiber, JL Jenkins, A Bender, M Milik, D Mikhailov, SCK Sukuru, ...
Statistical Analysis and Data Mining: The ASA Data Science Journal 2 (2 …, 2009
12009
Tubulysin analogs and methods for their preparation
C Subramanyam, LN Tumey, L Xie, C Leverett, BC Vetelino, SCK Sukuru, ...
US Patent 10,723,727, 2020
2020
Towards Addressing Informatics Challenges Presented by Antibody Drug Conjugates
C Sukuru, T Zhang, L Tumey, E Muszynska, M Tran, F Loganzo
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 250, 2015
2015
Benzosuberenes as cytotoxic tubulin binding agents
Z Chen, A Maderna, C Sukuru, F Loganzo
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 244, 2012
2012
Structural and statistical investigation of the trimethoxy-phenyl moiety in potent compounds that modulate multiple target classes
SCK Sukuru, JA Bikker, CJ O'Donnell
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 242, 2011
2011
Novel classification of proteases in the peptide substrate space reveals cross-family substrate similarities with applications to lead discovery
SCK Sukuru, F Nigsch, J Quancard, M Renatus, R Chopra, N Brooijmans, ...
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 240, 2010
2010
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