Olfactory transmucosal SARS-CoV-2 invasion as a port of central nervous system entry in individuals with COVID-19 J Meinhardt, J Radke, C Dittmayer, J Franz, C Thomas, R Mothes, M Laue, ... Nature neuroscience 24 (2), 168-175, 2021 | 1439 | 2021 |
SARS‐CoV‐2 receptor ACE 2 and TMPRSS 2 are primarily expressed in bronchial transient secretory cells S Lukassen, RL Chua, T Trefzer, NC Kahn, MA Schneider, T Muley, ... The EMBO journal 39 (10), e105114, 2020 | 1215 | 2020 |
COVID-19 severity correlates with airway epithelium–immune cell interactions identified by single-cell analysis RL Chua, S Lukassen, S Trump, BP Hennig, D Wendisch, F Pott, ... Nature biotechnology 38 (8), 970-979, 2020 | 1066 | 2020 |
SARS-CoV-2 infection triggers profibrotic macrophage responses and lung fibrosis D Wendisch, O Dietrich, T Mari, S von Stillfried, IL Ibarra, M Mittermaier, ... Cell 184 (26), 6243-6261. e27, 2021 | 367 | 2021 |
Pre-activated antiviral innate immunity in the upper airways controls early SARS-CoV-2 infection in children J Loske, J Röhmel, S Lukassen, S Stricker, VG Magalhães, J Liebig, ... Nature biotechnology 40 (3), 319-324, 2022 | 315 | 2022 |
SARS-CoV-2-mediated dysregulation of metabolism and autophagy uncovers host-targeting antivirals NC Gassen, J Papies, T Bajaj, J Emanuel, F Dethloff, RL Chua, J Trimpert, ... Nature communications 12 (1), 3818, 2021 | 220 | 2021 |
Untimely TGFβ responses in COVID-19 limit antiviral functions of NK cells M Witkowski, C Tizian, M Ferreira-Gomes, D Niemeyer, TC Jones, ... Nature 600 (7888), 295-301, 2021 | 199 | 2021 |
Hypertension delays viral clearance and exacerbates airway hyperinflammation in patients with COVID-19 S Trump, S Lukassen, MS Anker, RL Chua, J Liebig, L Thürmann, ... Nature biotechnology 39 (6), 705-716, 2021 | 172 | 2021 |
Loss of RNF40 decreases NF-κB activity in colorectal cancer cells and reduces colitis burden in mice RL Kosinsky, RL Chua, M Qui, D Saul, D Mehlich, P Ströbel, ... Journal of Crohn's and Colitis 13 (3), 362-373, 2019 | 34 | 2019 |
The E3 ubiquitin ligase RNF40 suppresses apoptosis in colorectal cancer cells D Schneider, RL Chua, N Molitor, FH Hamdan, EM Rettenmeier, ... Clinical Epigenetics 11, 1-13, 2019 | 28 | 2019 |
ELF5 is a potential respiratory epithelial cell-specific risk gene for severe COVID-19 M Pietzner, RL Chua, E Wheeler, K Jechow, JDS Willett, H Radbruch, ... Nature Communications 13 (1), 4484, 2022 | 18 | 2022 |
Proteomic and transcriptomic profiling of brainstem, cerebellum and olfactory tissues in early-and late-phase COVID-19 J Radke, J Meinhardt, T Aschman, RL Chua, V Farztdinov, S Lukassen, ... Nature Neuroscience 27 (3), 409-420, 2024 | 14 | 2024 |
Functional states in tumor-initiating cell differentiation in human colorectal cancer MK Zowada, SM Tirier, SM Dieter, TG Krieger, A Oberlack, RL Chua, ... Cancers 13 (5), 1097, 2021 | 10 | 2021 |
Intratumoral heterogeneity and immune modulation in lung adenocarcinoma in female smokers and never smokers TB Trefzer, MA Schneider, K Jechow, RL Chua, T Muley, H Winter, ... Cancer Research 82 (17), 3116-3129, 2022 | 5 | 2022 |
The central nervous system’s proteogenomic and spatial imprint upon systemic viral infections with SARS-CoV-2 J Radke, J Meinhardt, T Aschman, RL Chua, V Farztdinov, S Lukkassen, ... medRxiv, 2023.01. 16.22283804, 2023 | 4 | 2023 |
90K/LGALS3BP Expression is Upregulated in COVID-19 but Does Not Restrict SARS-CoV-2 Infection LB de Jarcy, B Akbil, J Leyens, D Postmus, G Harnisch, J Jansen, ... medRxiv, 2022.07. 18.22277255, 2022 | 1 | 2022 |
Profibrotic priming of airway cell types and drug responses in early-stage idiopathic pulmonary fibrosis RL Chua, C Veith, MA Schneider, K Jechow, EC Xu, M Kreuter, AW Boots, ... bioRxiv, 2022.03. 09.483638, 2022 | 1 | 2022 |
Epigenetic Perturbations in Upper Airway Cells in the Acute Phase of SARS-CoV-2 Infection Persistently Affect Their Transcriptional Programs S Trump, M Messingschlager, MT Voelker, S Mackowiak, M Bieg, ... B107. GENETIC AND TRANSCRIPTOMIC SIGNATURES IN LUNG DISEASES, A4894-A4894, 2024 | | 2024 |
90K/LGALS3BP expression is upregulated in COVID-19 but may not restrict SARS-CoV-2 infection L Bosquillon de Jarcy, B Akbil, B Mhlekude, J Leyens, D Postmus, ... Clinical and Experimental Medicine 23 (7), 3689-3700, 2023 | | 2023 |
Modelling early disease phenotypes of IPF airway cells and their drug responses RL Chua, C Veith, M Schneider, K Jechow, EC Xu, M Kreuter, A Boots, ... ERJ Open Research 9 (suppl 10), 2023 | | 2023 |