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Lea Scheppke
Lea Scheppke
Verified email at scripps.edu
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Cited by
Year
A role for VEGF as a negative regulator of pericyte function and vessel maturation
JI Greenberg, DJ Shields, SG Barillas, LM Acevedo, E Murphy, J Huang, ...
Nature 456 (7223), 809-813, 2008
7322008
MicroRNA-132–mediated loss of p120RasGAP activates the endothelium to facilitate pathological angiogenesis
S Anand, BK Majeti, LM Acevedo, EA Murphy, R Mukthavaram, ...
Nature medicine 16 (8), 909-914, 2010
6132010
Combination angiostatic therapy completely inhibits ocular and tumor angiogenesis
MI Dorrell, E Aguilar, L Scheppke, FH Barnett, M Friedlander
Proceedings of the National Academy of Sciences 104 (3), 967-972, 2007
2012007
Serine and lipid metabolism in macular disease and peripheral neuropathy
ML Gantner, K Eade, M Wallace, MK Handzlik, R Fallon, J Trombley, ...
New England Journal of Medicine 381 (15), 1422-1433, 2019
1712019
Notch promotes vascular maturation by inducing integrin-mediated smooth muscle cell adhesion to the endothelial basement membrane
L Scheppke, EA Murphy, A Zarpellon, JJ Hofmann, A Merkulova, ...
Blood, The Journal of the American Society of Hematology 119 (9), 2149-2158, 2012
1622012
Retinal vascular permeability suppression by topical application of a novel VEGFR2/Src kinase inhibitor in mice and rabbits
L Scheppke, E Aguilar, RF Gariano, R Jacobson, J Hood, J Doukas, ...
The Journal of clinical investigation 118 (6), 2337-2346, 2008
1402008
Genome-wide analyses identify common variants associated with macular telangiectasia type 2
TS Scerri, A Quaglieri, C Cai, J Zernant, N Matsunami, L Baird, ...
Nature Genetics 49 (4), 559-567, 2017
1092017
Angiogenesis and eye disease
Y Usui, PD Westenskow, S Murinello, MI Dorrell, L Scheppke, F Bucher, ...
Annual review of vision science 1, 155-184, 2015
542015
Three-dimensional in vivo imaging of the mouse intraocular vasculature during development and disease
MR Ritter, E Aguilar, E Banin, L Scheppke, H Uusitalo-Jarvinen, ...
Investigative ophthalmology & visual science 46 (9), 3021-3026, 2005
502005
Serine biosynthesis defect due to haploinsufficiency of PHGDH causes retinal disease
K Eade, ML Gantner, JA Hostyk, T Nagasaki, S Giles, R Fallon, ...
Nature metabolism 3 (3), 366-377, 2021
312021
Identification of genetic factors influencing metabolic dysregulation and retinal support for MacTel, a retinal disorder
R Bonelli, VE Jackson, A Prasad, JE Munro, S Farashi, TFC Heeren, ...
Communications biology 4 (1), 274, 2021
282021
A novel immunotherapy strategy for treatment of brain tumors through ex vivo manipulation of myeloid progenitor cells
FH Barnett, V Marchetti, M Wang, A Johnson, L Scheppke, R Jacobson, ...
Neuro-oncology 12, 35-35, 2010
22010
Self-Supervised Learning for Improved Optical Coherence Tomography Detection of Macular Telangiectasia Type 2
S Gholami, L Scheppke, M Kshirsagar, Y Wu, R Dodhia, R Bonelli, ...
JAMA ophthalmology, 2024
12024
Developing a Continuous Severity Scale for Macular Telangiectasia Type 2 Using Deep Learning and Implications for Disease Grading
Y Wu, C Egan, A Olvera-Barrios, L Scheppke, T Peto, PC Issa, ...
Ophthalmology 131 (2), 219-226, 2024
12024
Interpretable Ensemble-based Deep Learning Approach for Automated Detection of Macular Telangiectasia Type 2 by Optical Coherence Tomography
S Gholami, L Scheppke, RM Dodhia, JML Ferres, A Lee
ICML 3rd Workshop on Interpretable Machine Learning in Healthcare (IMLH), 2023
2023
Developing a continuous severity scale for Macular Telangiectasia
Y Wu, L Scheppke, CA Egan, A Olvera-Barrios, T Peto, CS Lee, EY Chew, ...
Investigative Ophthalmology & Visual Science 64 (8), 1287-1287, 2023
2023
Author Correction: Identification of genetic factors influencing metabolic dysregulation and retinal support for MacTel, a retinal disorder
R Bonelli, VE Jackson, A Prasad, JE Munro, S Farashi, TFC Heeren, ...
Communications Biology 4 (1), 473, 2021
2021
The role of dystrophin isoforms in retinal development and vaso-proliferative disease
M Friedlander, F Bucher, PD Westenskow, E Aguilar, SK Moreno, ...
Investigative Ophthalmology & Visual Science 57 (12), 4533-4533, 2016
2016
Microrna-132 Antagonism Potently Limits Neovascularization In Multiple Disease Models
PD Westenskow, T Kurihara, L Scheppke, S Moreno, E Aguilar, S Anand, ...
Investigative Ophthalmology & Visual Science 53 (14), 4120-4120, 2012
2012
Hypoxic Stress Induces Accelerated Pathological Angiogenesis and Gliosis in a Murine Model of Duchenne Muscular Dystrophy
M Friedlander, T Kurihara, PD Westenskow, L Scheppke, E Aguilar, ...
Investigative Ophthalmology & Visual Science 53 (14), 4122-4122, 2012
2012
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