XP Huang
XP Huang
Verified email at unc.edu
Cited by
Cited by
A SARS-CoV-2 protein interaction map reveals targets for drug repurposing
DE Gordon, GM Jang, M Bouhaddou, J Xu, K Obernier, KM White, ...
Nature 583 (7816), 459-468, 2020
Structure of the human κ-opioid receptor in complex with JDTic
H Wu, D Wacker, M Mileni, V Katritch, GW Han, E Vardy, W Liu, ...
Nature 485 (7398), 327-332, 2012
NMDAR inhibition-independent antidepressant actions of ketamine metabolites
P Zanos, R Moaddel, PJ Morris, P Georgiou, J Fischell, GI Elmer, ...
Nature 533 (7604), 481-486, 2016
Structure-based discovery of opioid analgesics with reduced side effects
A Manglik, H Lin, DK Aryal, JD McCorvy, D Dengler, G Corder, A Levit, ...
Nature 537 (7619), 185-190, 2016
Structural features for functional selectivity at serotonin receptors
D Wacker, C Wang, V Katritch, GW Han, XP Huang, E Vardy, JD McCorvy, ...
Science 340 (6132), 615-619, 2013
Automated design of ligands to polypharmacological profiles
J Besnard, GF Ruda, V Setola, K Abecassis, RM Rodriguiz, XP Huang, ...
Nature 492 (7428), 215-220, 2012
Structure of the nociceptin/orphanin FQ receptor in complex with a peptide mimetic
AA Thompson, W Liu, E Chun, V Katritch, H Wu, E Vardy, XP Huang, ...
Nature 485 (7398), 395-399, 2012
Structure of the human smoothened receptor bound to an antitumour agent
C Wang, H Wu, V Katritch, GW Han, XP Huang, W Liu, FY Siu, BL Roth, ...
Nature 497 (7449), 338-343, 2013
A chemical probe selectively inhibits G9a and GLP methyltransferase activity in cells
M Vedadi, D Barsyte-Lovejoy, F Liu, S Rival-Gervier, A Allali-Hassani, ...
Nature chemical biology 7 (8), 566-574, 2011
Structural basis for molecular recognition at serotonin receptors
C Wang, Y Jiang, J Ma, H Wu, D Wacker, V Katritch, GW Han, W Liu, ...
Science 340 (6132), 610-614, 2013
Molecular control of δ-opioid receptor signalling
G Fenalti, PM Giguere, V Katritch, XP Huang, AA Thompson, V Cherezov, ...
Nature 506 (7487), 191-196, 2014
An orally bioavailable chemical probe of the lysine methyltransferases EZH2 and EZH1
KD Konze, A Ma, F Li, D Barsyte-Lovejoy, T Parton, CJ MacNevin, F Liu, ...
ACS chemical biology 8 (6), 1324-1334, 2013
PRESTO-Tango as an open-source resource for interrogation of the druggable human GPCRome
WK Kroeze, MF Sassano, XP Huang, K Lansu, JD McCorvy, PM Gigučre, ...
Nature structural & molecular biology 22 (5), 362-369, 2015
Discovery of β-arrestin–biased dopamine D2 ligands for probing signal transduction pathways essential for antipsychotic efficacy
JA Allen, JM Yost, V Setola, X Chen, MF Sassano, M Chen, S Peterson, ...
Proceedings of the National Academy of Sciences 108 (45), 18488-18493, 2011
Amisulpride is a potent 5-HT 7 antagonist: relevance for antidepressant actions in vivo
AI Abbas, PB Hedlund, XP Huang, TB Tran, HY Meltzer, BL Roth
Psychopharmacology 205 (1), 119-128, 2009
A new DREADD facilitates the multiplexed chemogenetic interrogation of behavior
E Vardy, JE Robinson, C Li, RHJ Olsen, JF DiBerto, PM Giguere, ...
Neuron 86 (4), 936-946, 2015
Comprehensive characterization of the published kinase inhibitor set
JM Elkins, V Fedele, M Szklarz, KRA Azeez, E Salah, J Mikolajczyk, ...
Nature biotechnology 34 (1), 95-103, 2016
Structural basis for Smoothened receptor modulation and chemoresistance to anticancer drugs
C Wang, H Wu, T Evron, E Vardy, GW Han, XP Huang, SJ Hufeisen, ...
Nature communications 5 (1), 1-11, 2014
Structure of the nanobody-stabilized active state of the kappa opioid receptor
T Che, S Majumdar, SA Zaidi, P Ondachi, JD McCorvy, S Wang, ...
Cell 172 (1-2), 55-67. e15, 2018
Discovery of an in vivo chemical probe of the lysine methyltransferases G9a and GLP
F Liu, D Barsyte-Lovejoy, F Li, Y Xiong, V Korboukh, XP Huang, ...
Journal of medicinal chemistry 56 (21), 8931-8942, 2013
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