Macromolecular modeling and design in Rosetta: recent methods and frameworks JK Leman, BD Weitzner, SM Lewis, J Adolf-Bryfogle, N Alam, RF Alford, ... Nature methods 17 (7), 665-680, 2020 | 580 | 2020 |
Multivalent antibodies: when design surpasses evolution ÁM Cuesta, N Sainz-Pastor, J Bonet, B Oliva, L Álvarez-Vallina Trends in biotechnology 28 (7), 355-362, 2010 | 299 | 2010 |
Inferring causal molecular networks: empirical assessment through a community-based effort SM Hill, LM Heiser, T Cokelaer, M Unger, NK Nesser, DE Carlin, Y Zhang, ... Nature methods 13 (4), 310-318, 2016 | 238 | 2016 |
ADP-ribose–derived nuclear ATP synthesis by NUDIX5 is required for chromatin remodeling RHG Wright, A Lioutas, F Le Dily, D Soronellas, A Pohl, J Bonet, AS Nacht, ... Science 352 (6290), 1221-1225, 2016 | 166 | 2016 |
De novo protein design enables the precise induction of RSV-neutralizing antibodies F Sesterhenn, C Yang, J Bonet, JT Cramer, X Wen, Y Wang, CI Chiang, ... Science 368 (6492), eaay5051, 2020 | 155 | 2020 |
CDK2-dependent activation of PARP-1 is required for hormonal gene regulation in breast cancer cells RHG Wright, G Castellano, J Bonet, F Le Dily, J Font-Mateu, C Ballaré, ... Genes & development 26 (17), 1972-1983, 2012 | 134 | 2012 |
A computationally designed chimeric antigen receptor provides a small-molecule safety switch for T-cell therapy G Giordano-Attianese, P Gainza, E Gray-Gaillard, E Cribioli, S Shui, S Kim, ... Nature Biotechnology 38 (4), 426-432, 2020 | 122 | 2020 |
Rationale and design of a study assessing treatment strategies of atrial fibrillation in patients with heart failure: the Atrial Fibrillation and Congestive Heart Failure (AF … E Agner, L Aguinaga, HB Andersen, JMO Arnold, L Reisin, ... American Heart Journal 144 (4), 597-607, 2002 | 95 | 2002 |
Crowdsourced assessment of common genetic contribution to predicting anti-TNF treatment response in rheumatoid arthritis SK Sieberts, F Zhu, J García-García, E Stahl, A Pratap, G Pandey, ... Nature communications 7 (1), 12460, 2016 | 92 | 2016 |
Bottom-up de novo design of functional proteins with complex structural features C Yang, F Sesterhenn, J Bonet, EA van Aalen, L Scheller, LA Abriata, ... Nature Chemical Biology 17 (4), 492-500, 2021 | 87 | 2021 |
Early risks of death, stroke/systemic embolism, and major bleeding in patients with newly diagnosed atrial fibrillation: results from the GARFIELD-AF registry JP Bassand, S Virdone, SZ Goldhaber, AJ Camm, DA Fitzmaurice, ... Circulation 139 (6), 787-798, 2019 | 77 | 2019 |
In Vivo Tumor Targeting and Imaging with Engineered Trivalent Antibody Fragments Containing Collagen-Derived Sequences AM Cuesta, D Sánchez-Martín, L Sanz, J Bonet, M Compte, L Kremer, ... PLoS One 4 (4), e5381, 2009 | 77 | 2009 |
Characterization of protein hubs by inferring interacting motifs from protein interactions R Aragues, A Sali, J Bonet, MA Marti-Renom, B Oliva PLoS computational biology 3 (9), e178, 2007 | 77 | 2007 |
ATTACK, a novel bispecific T cell-recruiting antibody with trivalent EGFR binding and monovalent CD3 binding for cancer immunotherapy SL Harwood, A Alvarez-Cienfuegos, N Nuñez-Prado, M Compte, ... Oncoimmunology 7 (1), e1377874, 2018 | 76 | 2018 |
Amyloid-β peptide nitrotyrosination stabilizes oligomers and enhances NMDAR-mediated toxicity B Guivernau, J Bonet, V Valls-Comamala, M Bosch-Morató, JA Godoy, ... Journal of Neuroscience 36 (46), 11693-11703, 2016 | 64 | 2016 |
Management and 1‐year outcomes of patients with newly diagnosed atrial fibrillation and chronic kidney disease: results from the prospective GARFIELD‐AF registry S Goto, P Angchaisuksiri, JP Bassand, AJ Camm, H Dominguez, ... Journal of the American Heart Association 8 (3), e010510, 2019 | 60 | 2019 |
iLoops: a protein–protein interaction prediction server based on structural features J Planas-Iglesias, MA Marin-Lopez, J Bonet, J Garcia-Garcia, B Oliva Bioinformatics 29 (18), 2360-2362, 2013 | 55 | 2013 |
Understanding protein–protein interactions using local structural features J Planas-Iglesias, J Bonet, J Garcia-Garcia, MA Marin-Lopez, E Feliu, ... Journal of molecular biology 425 (7), 1210-1224, 2013 | 53 | 2013 |
ArchDB 2014: structural classification of loops in proteins J Bonet, J Planas-Iglesias, J Garcia-Garcia, MA Marín-López, ... Nucleic acids research 42 (D1), D315-D319, 2014 | 46 | 2014 |
Intramolecular trimerization, a novel strategy for making multispecific antibodies with controlled orientation of the antigen binding domains A Alvarez-Cienfuegos, N Nuñez-Prado, M Compte, AM Cuesta, ... Scientific reports 6 (1), 28643, 2016 | 40 | 2016 |