Franziska Marie Heydenreich
Franziska Marie Heydenreich
MRC Laboratory of Molecular Biology
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GPCR-G protein-β-arrestin super-complex mediates sustained G protein signaling
ARB Thomsen, B Plouffe, TJ Cahill, AK Shukla, JT Tarrasch, AM Dosey, ...
Cell 166 (4), 907-919, 2016
Diverse activation pathways in class A GPCRs converge near the G-protein-coupling region
AJ Venkatakrishnan, X Deupi, G Lebon, FM Heydenreich, T Flock, ...
Nature 536 (7617), 484-487, 2016
Backbone NMR reveals allosteric signal transduction networks in the β1-adrenergic receptor
S Isogai, X Deupi, C Opitz, FM Heydenreich, CJ Tsai, F Brueckner, ...
Nature 530 (7589), 237-241, 2016
A new inhibitor of the β-arrestin/AP2 endocytic complex reveals interplay between GPCR internalization and signalling
A Beautrait, JS Paradis, B Zimmerman, J Giubilaro, L Nikolajev, ...
Nature communications 8 (1), 15054, 2017
Stabilization of G protein-coupled receptors by point mutations
FM Heydenreich, Z Vuckovic, M Matkovic, DB Veprintsev
Frontiers in pharmacology 6, 82, 2015
How GPCR phosphorylation patterns orchestrate arrestin-mediated signaling
NR Latorraca, M Masureel, SA Hollingsworth, FM Heydenreich, ...
Cell 183 (7), 1813-1825. e18, 2020
Nitrogen and Carbon Status Are Integrated at the Transcriptional Level by the Nitrogen Regulator NtrC In Vivo
J Schumacher, V Behrends, Z Pan, DR Brown, F Heydenreich, MR Lewis, ...
MBio 4 (6), e00881-13, 2013
GPCR activation mechanisms across classes and macro/microscales
AS Hauser, AJ Kooistra, C Munk, FM Heydenreich, DB Veprintsev, ...
Nature structural & molecular biology 28 (11), 879-888, 2021
Activity of the mycobacterial proteasomal ATPase Mpa is reversibly regulated by pupylation
CL Delley, F Striebel, FM Heydenreich, D ÷zcelik, E Weber-Ban
Journal of Biological Chemistry 287 (11), 7907-7914, 2012
AAscan, PCRdesign and MutantChecker: a suite of programs for primer design and sequence analysis for high-throughput scanning mutagenesis
D Sun, MK Ostermaier, FM Heydenreich, D Mayer, R Jaussi, J Standfuss, ...
PLoS One 8 (10), e78878, 2013
High-throughput mutagenesis using a two-fragment PCR approach
FM Heydenreich, T Miljuš, R Jaussi, R Benoit, D Milić, DB Veprintsev
Scientific reports 7 (1), 1-11, 2017
GlnK facilitates the dynamic regulation of bacterial nitrogen assimilation
A Gosztolai, J Schumacher, V Behrends, JG Bundy, F Heydenreich, ...
Biophysical journal 112 (10), 2219-2230, 2017
The pocketome of G-protein-coupled receptors reveals previously untargeted allosteric sites
JB Hedderich, M Persechino, K Becker, FM Heydenreich, T Gutermuth, ...
Nature Communications 13 (1), 2567, 2022
Membrane phosphoinositides regulate GPCR-β-arrestin complex assembly and dynamics
J Janetzko, R Kise, B Barsi-Rhyne, DH Siepe, FM Heydenreich, ...
Cell 185 (24), 4560-4573. e19, 2022
Functional solubilisation of the β2-adrenoceptor (β2AR) using Diisobutylene maleic acid (DIBMA)
CR Harwood, DA Sykes, B Hoare, FM Heydenreich, R Uddin, DR Poyner, ...
bioRxiv, 2020.06. 29.171512, 2020
Membrane phosphoinositides stabilize GPCR-arrestin complexes and offer temporal control of complex assembly and dynamics
J Janetzko, R Kise, B Barsi-Ryne, DH Siepe, FM Heydenreich, ...
Biorxiv, 2021.10. 09.463790, 2021
Medical relevance of common protein-altering variants in GPCR genes across 337,205 individuals in the UK Biobank study
C DeBoever, AJ Venkatakrishnan, JM Paggi, FM Heydenreich, SA Laurin, ...
bioRxiv, 2019.12. 13.876250, 2019
Computationally designed GPCR quaternary structures bias signaling pathway activation
JS Paradis, X Feng, B Murat, RE Jefferson, B Sokrat, M Szpakowska, ...
Nature Communications 13 (1), 6826, 2022
Dissecting the allosteric networks governing agonist efficacy and potency in G protein-coupled receptors
FM Heydenreich, M Marti-Solano, M Sandhu, BK Kobilka, M Bouvier, ...
bioRxiv, 2021.09. 14.460253, 2021
Vasopressin V2 is a promiscuous G protein-coupled receptor that is biased by its peptide ligands
FM Heydenreich, B Plouffe, A Rizk, D Milić, J Zhou, B Breton, C Le Gouill, ...
bioRxiv, 2021.01. 28.427950, 2021
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