Sebastian Kelm
Sebastian Kelm
Principal Scientist, UCB
Verified email at
Cited by
Cited by
A multi-crystal method for extracting obscured crystallographic states from conventionally uninterpretable electron density
NM Pearce, T Krojer, AR Bradley, P Collins, RP Nowak, R Talon, ...
Nature communications 8 (1), 1-8, 2017
SAbPred: a structure-based antibody prediction server
J Dunbar, K Krawczyk, J Leem, C Marks, J Nowak, C Regep, G Georges, ...
Nucleic acids research 44 (W1), W474-W478, 2016
MEDELLER: homology-based coordinate generation for membrane proteins
S Kelm, J Shi, CM Deane
Bioinformatics 26 (22), 2833-2840, 2010
Observed antibody space: a resource for data mining next-generation sequencing of antibody repertoires
A Kovaltsuk, J Leem, S Kelm, J Snowden, CM Deane, K Krawczyk
The Journal of Immunology 201 (8), 2502-2509, 2018
Computational approaches to therapeutic antibody design: established methods and emerging trends
RA Norman, F Ambrosetti, AMJJ Bonvin, LJ Colwell, S Kelm, S Kumar, ...
Briefings in bioinformatics 21 (5), 1549-1567, 2020
Sphinx: merging knowledge-based and ab initio approaches to improve protein loop prediction
C Marks, J Nowak, S Klostermann, G Georges, J Dunbar, J Shi, S Kelm, ...
Bioinformatics 33 (9), 1346-1353, 2017
Memoir: template-based structure prediction for membrane proteins
JP Ebejer, JR Hill, S Kelm, J Shi, CM Deane
Nucleic acids research 41 (W1), W379-W383, 2013
Length-independent structural similarities enrich the antibody CDR canonical class model
J Nowak, T Baker, G Georges, S Kelm, S Klostermann, J Shi, S Sridharan, ...
MAbs 8 (4), 751-760, 2016
Structurally mapping antibody repertoires
K Krawczyk, S Kelm, A Kovaltsuk, JD Galson, D Kelly, J Trück, C Regep, ...
Frontiers in immunology 9, 1698, 2018
iMembrane: homology-based membrane-insertion of proteins
S Kelm, J Shi, CM Deane
Bioinformatics 25 (8), 1086-1088, 2009
Insight into small molecule binding to the neonatal Fc receptor by X-ray crystallography and 100 kHz magic-angle-spinning NMR
D Stöppler, A Macpherson, S Smith-Penzel, N Basse, F Lecomte, ...
PLoS biology 16 (5), e2006192, 2018
Structural diversity of B-cell receptor repertoires along the B-cell differentiation axis in humans and mice
A Kovaltsuk, MIJ Raybould, WK Wong, C Marks, S Kelm, J Snowden, ...
PLoS computational biology 16 (2), e1007636, 2020
Environment specific substitution tables improve membrane protein alignment
JR Hill, S Kelm, J Shi, CM Deane
Bioinformatics 27 (13), i15-i23, 2011
Examining the conservation of kinks in alpha helices
EC Law, HR Wilman, S Kelm, J Shi, CM Deane
PloS one 11 (6), e0157553, 2016
Reconstruction of apo A2A receptor activation pathways reveal ligand-competent intermediates and state-dependent cholesterol hotspots
S Lovera, A Cuzzolin, S Kelm, G De Fabritiis, ZA Sands
Scientific reports 9 (1), 1-10, 2019
Crystal structure of dopamine D1 receptor in complex with G protein and a non-catechol agonist
B Sun, D Feng, MLH Chu, I Fish, S Lovera, ZA Sands, S Kelm, A Valade, ...
Nature communications 12 (1), 1-9, 2021
SCALOP: sequence-based antibody canonical loop structure annotation
WK Wong, G Georges, F Ros, S Kelm, AP Lewis, B Taddese, J Leem, ...
Bioinformatics 35 (10), 1774-1776, 2019
B-cell epitopes: Discontinuity and conformational analysis
S Ferdous, S Kelm, TS Baker, J Shi, ACR Martin
Molecular immunology 114, 643-650, 2019
Electrostatic interactions modulate the differential aggregation propensities of IgG1 and IgG4P antibodies and inform charged residue substitutions for improved developability
JT Heads, R Lamb, S Kelm, R Adams, P Elliott, K Tyson, S Topia, S West, ...
Protein Engineering, Design and Selection 32 (6), 277-288, 2019
Fragment‐based modeling of membrane protein loops: Successes, failures, and prospects for the future
S Kelm, A Vangone, Y Choi, JP Ebejer, J Shi, CM Deane
Proteins: Structure, Function, and Bioinformatics 82 (2), 175-186, 2014
The system can't perform the operation now. Try again later.
Articles 1–20