High-resolution crystal structure of an engineered human β2-adrenergic G protein–coupled receptor V Cherezov, DM Rosenbaum, MA Hanson, SGF Rasmussen, FS Thian, ... science 318 (5854), 1258-1265, 2007 | 3927 | 2007 |
Crystal structure of the β2 adrenergic receptor–Gs protein complex SGF Rasmussen, BT DeVree, Y Zou, AC Kruse, KY Chung, TS Kobilka, ... Nature 477 (7366), 549-555, 2011 | 3213 | 2011 |
The structure and function of G-protein-coupled receptors DM Rosenbaum, SGF Rasmussen, BK Kobilka Nature 459 (7245), 356-363, 2009 | 2669 | 2009 |
Crystal structure of the human β2 adrenergic G-protein-coupled receptor SGF Rasmussen, HJ Choi, DM Rosenbaum, TS Kobilka, FS Thian, ... Nature 450 (7168), 383-387, 2007 | 2508 | 2007 |
Structure of a nanobody-stabilized active state of the β2 adrenoceptor SGF Rasmussen, HJ Choi, JJ Fung, E Pardon, P Casarosa, PS Chae, ... Nature 469 (7329), 175-180, 2011 | 1880 | 2011 |
GPCR engineering yields high-resolution structural insights into β2-adrenergic receptor function DM Rosenbaum, V Cherezov, MA Hanson, SGF Rasmussen, FS Thian, ... science 318 (5854), 1266-1273, 2007 | 1689 | 2007 |
Cloning of the gene and cDNA for mammalian β-adrenergic receptor and homology with rhodopsin RAF Dixon, BK Kobilka, DJ Strader, JL Benovic, HG Dohlman, T Frielle, ... Nature 321 (6065), 75-79, 1986 | 1681 | 1986 |
Crystal structure of the µ-opioid receptor bound to a morphinan antagonist A Manglik, AC Kruse, TS Kobilka, FS Thian, JM Mathiesen, RK Sunahara, ... Nature 485 (7398), 321-326, 2012 | 1491 | 2012 |
Functional selectivity and classical concepts of quantitative pharmacology JD Urban, WP Clarke, M Von Zastrow, DE Nichols, B Kobilka, H Weinstein, ... Journal of Pharmacology and Experimental Therapeutics 320 (1), 1-13, 2007 | 1257 | 2007 |
Chimeric α2-,β2-Adrenergic Receptors: Delineation of Domains Involved in Effector Coupling and Ligand Binding Specificity BK Kobilka, TS Kobilka, K Daniel, JW Regan, MG Caron, RJ Lefkowitz Science 240 (4857), 1310-1316, 1988 | 1048 | 1988 |
βAR signaling required for diet-induced thermogenesis and obesity resistance ES Bachman, H Dhillon, CY Zhang, S Cinti, AC Bianco, BK Kobilka, ... Science 297 (5582), 843-845, 2002 | 994 | 2002 |
Cloning, Sequencing, and Expression of the Gene Coding for the Human Platelet α2-Adrenergic Receptor BK Kobilka, H Matsui, TS Kobilka, TL Yang-Feng, U Francke, MG Caron, ... Science 238 (4827), 650-656, 1987 | 971 | 1987 |
cDNA for the human beta 2-adrenergic receptor: a protein with multiple membrane-spanning domains and encoded by a gene whose chromosomal location is shared with that of the … BK Kobilka, RA Dixon, T Frielle, HG Dohlman, MA Bolanowski, IS Sigal, ... Proceedings of the National Academy of Sciences 84 (1), 46-50, 1987 | 903 | 1987 |
Activation and allosteric modulation of a muscarinic acetylcholine receptor AC Kruse, AM Ring, A Manglik, J Hu, K Hu, K Eitel, H Hübner, E Pardon, ... Nature 504 (7478), 101-106, 2013 | 889 | 2013 |
Structure and function of an irreversible agonist-β2 adrenoceptor complex DM Rosenbaum, C Zhang, JA Lyons, R Holl, D Aragao, DH Arlow, ... Nature 469 (7329), 236-240, 2011 | 888 | 2011 |
Structure of the human M2 muscarinic acetylcholine receptor bound to an antagonist K Haga, AC Kruse, H Asada, T Yurugi-Kobayashi, M Shiroishi, C Zhang, ... Nature 482 (7386), 547-551, 2012 | 882 | 2012 |
Structure and dynamics of the M3 muscarinic acetylcholine receptor AC Kruse, J Hu, AC Pan, DH Arlow, DM Rosenbaum, E Rosemond, ... Nature 482 (7386), 552-556, 2012 | 868 | 2012 |
Conformational complexity of G-protein-coupled receptors BK Kobilka, X Deupi Trends in pharmacological sciences 28 (8), 397-406, 2007 | 862 | 2007 |
Behavioural and cardiovascular effects of disrupting the angiotensin II type-2 receptor gene in mice L Hein, GS Barsh, RE Pratt, VJ Dzau, BK Kobilka Nature 377 (6551), 744-747, 1995 | 859 | 1995 |
G protein-coupled receptors: II. Mechanism of agonist activation U Gether, BK Kobilka Journal of Biological Chemistry 273 (29), 17979-17982, 1998 | 857 | 1998 |