David Grahame Hardie
David Grahame Hardie
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Zitiert von
Zitiert von
AMPK: a nutrient and energy sensor that maintains energy homeostasis
DG Hardie, FA Ross, SA Hawley
Nature reviews Molecular cell biology 13 (4), 251-262, 2012
AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism
BB Kahn, T Alquier, D Carling, DG Hardie
Cell metabolism 1 (1), 15-25, 2005
AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy
DG Hardie
Nature reviews Molecular cell biology 8 (10), 774-785, 2007
The mechanisms of action of metformin
G Rena, DG Hardie, ER Pearson
Diabetologia 60 (9), 1577-1585, 2017
Complexes between the LKB1 tumor suppressor, STRADα/β and MO25α/β are upstream kinases in the AMP-activated protein kinase cascade
SA Hawley, J Boudeau, JL Reid, KJ Mustard, L Udd, TP Mäkelä, ...
Journal of biology 2, 1-16, 2003
Calmodulin-dependent protein kinase kinase-β is an alternative upstream kinase for AMP-activated protein kinase
SA Hawley, DA Pan, KJ Mustard, L Ross, J Bain, AM Edelman, ...
Cell metabolism 2 (1), 9-19, 2005
The AMP-activated/SNF1 protein kinase subfamily: metabolic sensors of the eukaryotic cell?
DG Hardie, D Carling, M Carlson
Annual review of biochemistry 67 (1), 821-855, 1998
AMP-activated protein kinase—an energy sensor that regulates all aspects of cell function
DG Hardie
Genes & development 25 (18), 1895-1908, 2011
The AMP‐activated protein kinase: fuel gauge of the mammalian cell?
DG Hardie, D Carling
European journal of biochemistry 246 (2), 259-273, 1997
AMP-activated protein kinase in metabolic control and insulin signaling
MC Towler, DG Hardie
Circulation research 100 (3), 328-341, 2007
LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR‐1
JM Lizcano, O Göransson, R Toth, M Deak, NA Morrice, J Boudeau, ...
The EMBO journal 23 (4), 833-843, 2004
Characterization of the AMP-activated protein kinase kinase from rat liver and identification of threonine 172 as the major site at which it phosphorylates AMP-activated …
SA Hawley, M Davison, A Woods, SP Davies, RK Beri, D Carling, ...
Journal of Biological Chemistry 271 (44), 27879-27887, 1996
5‐Aminoimidazole‐4‐carboxamide ribonucleoside: a specific method for activating AMP‐activated protein kinase in intact cells?
JM Corton, JG Gillespie, SA Hawley, DG Hardie
European journal of biochemistry 229 (2), 558-565, 1995
The AMP-activated protein kinase pathway–new players upstream and downstream
DG Hardie
Journal of cell science 117 (23), 5479-5487, 2004
AMP-activated protein kinase, a metabolic master switch: possible roles in type 2 diabetes
WW Winder, DG Hardie
American Journal of Physiology-Endocrinology and Metabolism 277 (1), E1-E10, 1999
AICA riboside increases AMP-activated protein kinase, fatty acid oxidation, and glucose uptake in rat muscle
GF Merrill, EJ Kurth, DG Hardie, WW Winder
American Journal of Physiology-Endocrinology and Metabolism 273 (6), E1107-E1112, 1997
Minireview: the AMP-activated protein kinase cascade: the key sensor of cellular energy status
DG Hardie
Endocrinology 144 (12), 5179-5183, 2003
Metabolism of inflammation limited by AMPK and pseudo-starvation
LAJ O'Neill, DG Hardie
Nature 493 (7432), 346-355, 2013
Inactivation of acetyl-CoA carboxylase and activation of AMP-activated protein kinase in muscle during exercise
WW Winder, DG Hardie
American Journal of Physiology-Endocrinology and Metabolism 270 (2), E299-E304, 1996
Management of cellular energy by the AMP-activated protein kinase system
DG Hardie, JW Scott, DA Pan, ER Hudson
FEBS letters 546 (1), 113-120, 2003
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