Segui
zlem Demir
zlem Demir
Scientist at Takeda Pharmaceuticals & Visiting Scholar at University of California-San Diego
Email verificata su ucsd.edu
Titolo
Citata da
Citata da
Anno
Ensemble Docking in Drug Discovery
RE Amaro, J Baudry, J Chodera, Demir, JA McCammon, Y Miao, F Noe, ...
Biophysical J. 114, 1-8, 2018
3792018
Structural basis for targeted DNA cytosine deamination and mutagenesis by APOBEC3A and APOBEC3B
K Shi, MA Carpenter, S Banerjee, NM Shaban, K Kurahashi, ...
Nature structural & molecular biology 24 (2), 131-139, 2017
2472017
Computational identification of a transiently open L1/S3 pocket for reactivation of mutant p53
CD Wassman, R Baronio, Demir, BD Wallentine, CK Chen, LV Hall, ...
Nature communications 4, 1407, 2013
2302013
The local dinucleotide preference of APOBEC3G can be altered from 5′-CC to 5′-TC by a single amino acid substitution
A Rathore, MA Carpenter, Demir, T Ikeda, M Li, NM Shaban, EK Law, ...
Journal of molecular biology 425 (22), 4442-4454, 2013
1092013
Structure and dynamics of SARS-CoV-2 proofreading exoribonuclease ExoN
NH Moeller, K Shi, Demir, C Belica, S Banerjee, L Yin, C Durfee, ...
Proceedings of the National Academy of Sciences 119 (9), e2106379119, 2022
1002022
APOBEC3B Nuclear Localization Requires Two Distinct N-Terminal Domain Surfaces
DJ Salamango, JL McCann, Demir, WL Brown, RE Amaro, RS Harris
J. Mol. Biol. 430 (17), 2695-2708, 2018
532018
Ensemble-based computational approach discriminates functional activity of p53 cancer and rescue mutants
Demir, R Baronio, F Salehi, CD Wassman, L Hall, GW Hatfield, ...
PLoS computational biology 7 (10), e1002238, 2011
532011
The binding interface between human APOBEC3F and HIV-1 Vif elucidated by genetic and computational approaches
C Richards, JS Albin, Demir, NM Shaban, EM Luengas, AM Land, ...
Cell reports 13 (9), 1781-1788, 2015
442015
Adapting AlphaLISA high throughput screen to discover a novel small-molecule inhibitor targeting protein arginine methyltransferase 5 in pancreatic and colorectal cancers
L Prabhu, H Wei, L Chen, Demir, G Sandusky, E Sun, J Wang, J Mo, ...
Oncotarget 8 (25), 39963, 2017
432017
Modulation of catalytic function by differential plasticity of the active site: case study of Trypanosoma cruzi trans-sialidase and Trypanosoma rangeli sialidase
Demir, AE Roitberg
Biochemistry 48 (15), 3398, 2009
422009
Development of AlphaLISA high throughput technique to screen for small molecule inhibitors targeting protein arginine methyltransferases
L Prabhu, L Chen, H Wei, O Demir, A Safa, LF Zeng, R Amaro, BH O'Neil, ...
Molecular Biosystems, 2017
362017
Conformational Switch Regulates the DNA Cytosine Deaminase Activity of Human APOBEC3B
K Shi, Demir, MA Carpenter, J Wagner, K Kurahashi, RS Harris, ...
Scientific reports 7 (1), 17415, 2017
352017
Full-length p53 tetramer bound to DNA and its quaternary dynamics
Demir, PU Ieong, RE Amaro
Oncogene 36 (10), 1451-1460, 2017
342017
Markov state models and NMR uncover an overlooked allosteric loop in p53
EP Barros, Demir, J Soto, MJ Cocco, RE Amaro
Chemical Science 12 (5), 1891-1900, 2021
292021
An integrated view of p53 dynamics, function, and reactivation
Demir, EP Barros, TL Offutt, M Rosenfeld, RE Amaro
Current Opinion in Structural Biology 67, 187-194, 2021
272021
Molecular docking to flexible targets
J Srensen, Demir, RV Swift, VA Feher, RE Amaro
Molecular Modeling of Proteins, 445-469, 2015
252015
APOBEC3H subcellular localization determinants define zipcode for targeting HIV-1 for restriction
DJ Salamango, JT Becker, JL McCann, AZ Cheng, Demir, RE Amaro, ...
Molecular and cellular biology 38 (23), e00356-18, 2018
232018
Neolymphostin A is a covalent phosphoinositide 3-kinase (PI3K)/mammalian target of rapamycin (mTOR) dual inhibitor that employs an unusual electrophilic vinylogous ester
G Castro-Falcn, GS Seiler, O Demir, MK Rathinaswamy, D Hamelin, ...
Journal of medicinal chemistry 61 (23), 10463-10472, 2018
212018
The substrate-binding cap of the UDP-diacylglucosamine pyrophosphatase LpxH is highly flexible, enabling facile substrate binding and product release
TE Bohl, P Ieong, JK Lee, T Lee, J Kankanala, K Shi, Demir, ...
J. Biol. Chem., 2018
152018
Computer‐Aided Discovery of Trypanosoma brucei RNA‐Editing Terminal Uridylyl Transferase 2 Inhibitors
Demir, M Labaied, C Merritt, K Stuart, RE Amaro
Chemical biology & drug design 84 (2), 131-139, 2014
152014
Il sistema al momento non pu eseguire l'operazione. Riprova pi tardi.
Articoli 1–20