| Hydrogen peroxide sensor HPCA1 is an LRR receptor kinase in Arabidopsis F Wu, Y Chi, Z Jiang, Y Xu, L Xie, F Huang, DI Wan, J Ni, F Yuan, X Wu, ... Nature 578 (7796), 577-581, 2020 | 370 | 2020 |
| Discovery of potent and selective epidermal growth factor receptor (EGFR) bifunctional small-molecule degraders M Cheng, X Yu, K Lu, L Xie, L Wang, F Meng, X Han, X Chen, J Liu, ... Journal of medicinal chemistry 63 (3), 1216-1232, 2020 | 126 | 2020 |
| Harnessing the E3 ligase KEAP1 for targeted protein degradation J Wei, F Meng, KS Park, H Yim, J Velez, P Kumar, L Wang, L Xie, H Chen, ... Journal of the American Chemical Society 143 (37), 15073-15083, 2021 | 76 | 2021 |
| Multi-omics analyses reveal that HIV-1 alters CD4+ T cell immunometabolism to fuel virus replication H Guo, QI Wang, K Ghneim, LI Wang, E Rampanelli, E Holley-Guthrie, ... Nature immunology 22 (4), 423-433, 2021 | 69 | 2021 |
| Whole human genome proteogenomic mapping for ENCODE cell line data: identifying protein-coding regions J Khatun, Y Yu, JA Wrobel, BA Risk, HP Gunawardena, A Secrest, ... BMC genomics 14, 1-11, 2013 | 69 | 2013 |
| Discovery of first-in-class protein arginine methyltransferase 5 (PRMT5) degraders Y Shen, G Gao, X Yu, H Kim, L Wang, L Xie, M Schwarz, X Chen, ... Journal of medicinal chemistry 63 (17), 9977-9989, 2020 | 66 | 2020 |
| Discovery of a first-in-class mitogen-activated protein kinase kinase 1/2 degrader J Wei, J Hu, L Wang, L Xie, MS Jin, X Chen, J Liu, J Jin Journal of medicinal chemistry 62 (23), 10897-10911, 2019 | 50 | 2019 |
| Protein phosphatase 2A catalytic subunit α plays a MyD88-dependent, central role in the gene-specific regulation of endotoxin tolerance L Xie, C Liu, L Wang, HP Gunawardena, Y Yu, R Du, DJ Taxman, P Dai, ... Cell reports 3 (3), 678-688, 2013 | 42 | 2013 |
| Distinct CDK6 complexes determine tumor cell response to CDK4/6 inhibitors and degraders X Wu, X Yang, Y Xiong, R Li, T Ito, TA Ahmed, Z Karoulia, C Adamopoulos, ... Nature cancer 2 (4), 429-443, 2021 | 38 | 2021 |
| Design, synthesis, and evaluation of potent, selective, and bioavailable AKT kinase degraders X Yu, J Xu, L Xie, L Wang, Y Shen, KM Cahuzac, X Chen, J Liu, ... Journal of medicinal chemistry 64 (24), 18054-18081, 2021 | 29 | 2021 |
| Proteomic dissection of LPS-inducible, PHF8-dependent secretome reveals novel roles of PHF8 in TLR4-induced acute inflammation and T cell proliferation Ö Erdoğan, L Xie, L Wang, B Wu, Q Kong, Y Wan, X Chen Scientific reports 6 (1), 24833, 2016 | 28 | 2016 |
| Potent and selective mitogen-activated protein kinase kinase 1/2 (MEK1/2) heterobifunctional small-molecule degraders J Hu, J Wei, H Yim, L Wang, L Xie, MS Jin, M Kabir, L Qin, X Chen, J Liu, ... Journal of medicinal chemistry 63 (24), 15883-15905, 2020 | 26 | 2020 |
| Non-canonical bromodomain within DNA-PKcs promotes DNA damage response and radioresistance through recognizing an IR-induced acetyl-lysine on H2AX L Wang, L Xie, S Ramachandran, YY Lee, Z Yan, L Zhou, K Krajewski, ... Chemistry & biology 22 (7), 849-861, 2015 | 24 | 2015 |
| TNRC6 proteins modulate hepatitis C virus replication by spatially regulating the binding of miR-122/Ago2 complexes to viral RNA Y Li, L Wang, EE Rivera-Serrano, X Chen, SM Lemon Nucleic Acids Research 47 (12), 6411-6424, 2019 | 20 | 2019 |
| Novel RNA-affinity proteogenomics dissects tumor heterogeneity for revealing personalized markers in precision prognosis of cancer L Wang, JA Wrobel, L Xie, DX Li, G Zurlo, H Shen, P Yang, Z Wang, ... Cell chemical biology 25 (5), 619-633. e5, 2018 | 17 | 2018 |
| Novel secretome-to-transcriptome integrated or secreto-transcriptomic approach to reveal liquid biopsy biomarkers for predicting individualized prognosis of breast cancer patients JA Ankney, L Xie, JA Wrobel, L Wang, X Chen BMC Medical Genomics 12, 1-20, 2019 | 15 | 2019 |
| Positive cooperativity in substrate binding by human thymidylate synthase JP Bonin, PJ Sapienza, E Wilkerson, D Goldfarb, L Wang, L Herring, ... Biophysical journal 117 (6), 1074-1084, 2019 | 14 | 2019 |
| Analysis of mammalian circadian clock protein complexes over a circadian cycle X Cao, L Wang, CP Selby, LA Lindsey-Boltz, A Sancar Journal of Biological Chemistry 299 (3), 2023 | 12 | 2023 |
| Novel gene-specific translation mechanism of dysregulated, chronic inflammation reveals promising, multifaceted COVID-19 therapeutics L Wang, A Muneer, L Xie, F Zhang, B Wu, L Mei, EM Lenarcic, EH Feng, ... bioRxiv, 2020.11. 14.382416, 2020 | 11 | 2020 |
| Crotonylation sensitizes IAPi-induced disruption of latent HIV by enhancing p100 cleavage into p52 D Li, MG Dewey, L Wang, SD Falcinelli, LM Wong, Y Tang, EP Browne, ... Iscience 25 (1), 2022 | 10 | 2022 |
