A new allosteric site in glycogen phosphorylase b as a target for drug interactions NG Oikonomakos, VT Skamnaki, KE Tsitsanou, NG Gavalas, LN Johnson Structure 8 (6), 575-584, 2000 | 184 | 2000 |
Flavopiridol inhibits glycogen phosphorylase by binding at the inhibitor site NG Oikonomakos, JB Schnier, SE Zographos, VT Skamnaki, ... Journal of Biological Chemistry 275 (44), 34566-34573, 2000 | 171 | 2000 |
Anopheles gambiae odorant binding protein crystal complex with the synthetic repellent DEET: implications for structure-based design of novel mosquito repellents KE Tsitsanou, T Thireou, CE Drakou, K Koussis, MV Keramioti, ... Cellular and Molecular Life Sciences 69, 283-297, 2012 | 123 | 2012 |
The structure of glycogen phosphorylase b with an alkyldihydropyridine-dicarboxylic acid compound, a novel and potent inhibitor SE Zographos, NG Oikonomakos, KE Tsitsanou, DD Leonidas, ... Structure 5 (11), 1413-1425, 1997 | 112 | 1997 |
Allosteric inhibition of glycogen phosphorylase a by the potential antidiabetic drug 3-isopropyl 4-(2-chlorophenyl)-1, 4-dihydro-1-ethyl-2-methyl-pyridine-3, 5, 6-tricarboxylate NG Oikonomakos, KE Tsitsanou, SE Zographos, VT Skamnaki, ... Protein Science 8 (10), 1930-1945, 1999 | 77 | 1999 |
Cooperative Interactions of the Catalytic Nucleophile and the Catalytic Acid in the Inhibition of β‐Glycosidases. Calculations and their validation by comparative kinetic and … TD Heightman, A Vasella, KE Tsitsanou, SE Zographos, VT Skamnaki, ... Helvetica chimica acta 81 (5‐8), 853-864, 1998 | 74 | 1998 |
Triazole carboxylic acids as anionic sugar mimics? Inhibition of glycogen phosphorylase by a D-glucotriazole carboxylate TM Krülle, C de la Fuente, L Pickering, RT Aplin, KE Tsitsanou, ... Tetrahedron: Asymmetry 8 (22), 3807-3820, 1997 | 72 | 1997 |
Specific inhibition of glycogen phosphorylase by a spirodiketopiperazine at the anomeric position of glucopyranose TM Krülle, KA Watson, M Gregoriou, LN Johnson, S Crook, DJ Watkin, ... Tetrahedron letters 36 (45), 8291-8294, 1995 | 63 | 1995 |
The crystal structure of the AgamOBP1• Icaridin complex reveals alternative binding modes and stereo-selective repellent recognition CE Drakou, KE Tsitsanou, C Potamitis, D Fessas, M Zervou, ... Cellular and Molecular Life Sciences 74, 319-338, 2017 | 48 | 2017 |
Structural basis of the synergistic inhibition of glycogen phosphorylase a by caffeine and a potential antidiabetic drug KE Tsitsanou, VT Skamnaki, NG Oikonomakos Archives of biochemistry and biophysics 384 (2), 245-254, 2000 | 47 | 2000 |
Effects of commonly used cryoprotectants on glycogen phosphorylase activity and structure KE Tsitsanou, NG Oikonomakos, SE Zographos, VT Skamnaki, ... Protein Science 8 (4), 741-749, 1999 | 47 | 1999 |
Crystal and solution studies of the “Plus-C” odorant-binding protein 48 from Anopheles gambiae: control of binding specificity through three-dimensional domain swapping KE Tsitsanou, CE Drakou, T Thireou, AV Gruber, G Kythreoti, A Azem, ... Journal of Biological Chemistry 288 (46), 33427-33438, 2013 | 43 | 2013 |
Sourcing the affinity of flavonoids for the glycogen phosphorylase inhibitor site via crystallography, kinetics and QM/MM-PBSA binding studies: comparison of chrysin and … KE Tsitsanou, JM Hayes, M Keramioti, M Mamais, NG Oikonomakos, ... Food and chemical toxicology 61, 14-27, 2013 | 40 | 2013 |
A galactopyranose analogue of hydantocidin TW Brandstetter, MR Wormald, RA Dwek, TD Butters, FM Platt, ... Tetrahedron: Asymmetry 7 (1), 157-170, 1996 | 39 | 1996 |
Identification of novel bioinspired synthetic mosquito repellents by combined ligand-based screening and OBP-structure-based molecular docking T Thireou, G Kythreoti, KE Tsitsanou, K Koussis, CE Drakou, J Kinnersley, ... Insect biochemistry and molecular biology 98, 48-61, 2018 | 36 | 2018 |
Kinetic and crystallographic studies of glucopyranose spirohydantoin and glucopyranosylamine analogs inhibitors of glycogen phosphorylase KA Watson, ED Chrysina, KE Tsitsanou, SE Zographos, G Archontis, ... Proteins: Structure, Function, and Bioinformatics 61 (4), 966-983, 2005 | 33 | 2005 |
Stereospecific synthesis of spirohydantoins of β-glucopyranose: inhibitors of glycogen phosphorylase TM Krülle, C de la Fuente, KA Watson, M Gregoriou, LN Johnson, ... Synlett 1997 (02), 211-213, 1997 | 28 | 1997 |
Glucofuranose analogues of hydantocidin TW Brandstetter, C de la Fuente, Y Kim, LN Johnson, S Crook, PMQ Lilley, ... Tetrahedron 52 (32), 10721-10736, 1996 | 28 | 1996 |
Glucopyranose spirohydantoins: specific inhibitors of glycogen phosphorylase C delaFuente, T Krulle, K Watson, M Gregoriou, L Johnson, K Tsitsanou, ... Synlett 1997 (5), 1997 | 23 | 1997 |
Glycogen phosphorylase revisited: extending the resolution of the R-and T-state structures of the free enzyme and in complex with allosteric activators DD Leonidas, SE Zographos, KE Tsitsanou, VT Skamnaki, G Stravodimos, ... Acta Crystallographica Section F: Structural Biology Communications 77 (9 …, 2021 | 13 | 2021 |