Alejandro Chavez

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George ChurchHarvard Medical SchoolVerified email at harvard.edu
James J CollinsMIT; Wyss Institute, Harvard; Broad Institute of MIT & HarvardVerified email at mit.edu
Benjamin W Pruitt10x GenomicsVerified email at 10xgenomics.com
Xiaoge GuoNabla Bio / Wyss Institute at Harvard / Harvard Medical SchoolVerified email at wyss.harvard.edu
Samira KianiSchool of Biological and Health Systems Engineering-Arizona State UniversityVerified email at asu.edu
David Hoprofessor of medicine, Columbia universityVerified email at cumc.columbia.edu
Sho IketaniColumbia University Medical CenterVerified email at cumc.columbia.edu
Rebecca S ShapiroAssociate Professor, University of GuelphVerified email at uoguelph.ca
F. Brad Johnson, MD, PhDProfessor of Pathology and Laboratory MedicineVerified email at pennmedicine.upenn.edu
James E. DiCarloVertex PharmaceuticalsVerified email at vrtx.com
Raj ChariLeidos Biomedical Research, Frederick National Lab for Cancer ResearchVerified email at nih.gov
Ron WeissProfessor of Biological Engineering, Massachusetts Institute of TechnologyVerified email at mit.edu
Bruce CulbertsonMD/PhD candidate, Columbia UniversityVerified email at cumc.columbia.edu
Yosef SaboDepartment of Medicine / ADARC, Columbia UniversityVerified email at cumc.columbia.edu
Mo EbrahimkhaniAssociate professor, Department of Pathology, University of PittsburghVerified email at pitt.edu
Stephen P. GoffProfessor of Biochemistry and Molecular Biophysics, Columbia UniversityVerified email at cumc.columbia.edu
Kevin EsveltAssociate Professor, MIT Media LabVerified email at mit.edu
Avinash BhandoolaLGI, NCI, NIHVerified email at nih.gov
Richard I. MorimotoBill and Gayle Cook Professor of Biology, Dept of Molecular Biosciences, NorthwesternVerified email at northwestern.edu
Ronald PlasterkVerified email at tiscali.nl

Alejandro Chavez

Associate Professor - University of California San Diego

Verified email at health.ucsd.edu - Homepage

Synthetic biology Genome engineering High-throughput Screening Neurodegenerative Disease


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Age-related clonal hematopoiesis associated with adverse outcomes S Jaiswal, P Fontanillas, J Flannick, A Manning, PV Grauman, BG Mar, ... New England Journal of Medicine 371 (26), 2488-2498, 2014	4819	2014
Highly efficient Cas9-mediated transcriptional programming A Chavez, J Scheiman, S Vora, BW Pruitt, M Tuttle, E PR Iyer, S Lin, ... Nature methods 12 (4), 326-328, 2015	1749	2015
Comparison of Cas9 activators in multiple species A Chavez, M Tuttle, BW Pruitt, B Ewen-Campen, R Chari, ... Nature methods 13 (7), 563-567, 2016	615	2016
Genome-wide RNA interference screen identifies previously undescribed regulators of polyglutamine aggregation EAA Nollen, SM Garcia, G Van Haaften, S Kim, A Chavez, RI Morimoto, ... Proceedings of the National Academy of Sciences of the United States of …, 2004	522	2004
An enhanced CRISPR repressor for targeted mammalian gene regulation NC Yeo, A Chavez, A Lance-Byrne, Y Chan, D Menn, D Milanova, ... Nature methods 15 (8), 611-616, 2018	510	2018
Programmable transcriptional repression in mycobacteria using an orthogonal CRISPR interference platform JM Rock, FF Hopkins, A Chavez, M Diallo, MR Chase, ER Gerrick, ... Nature microbiology 2 (4), 1-9, 2017	502	2017
A critical role for TCF-1 in T-lineage specification and differentiation BN Weber, AWS Chi, A Chavez, Y Yashiro-Ohtani, Q Yang, O Shestova, ... Nature 476 (7358), 63-68, 2011	478	2011
Safeguarding CRISPR-Cas9 gene drives in yeast JE DiCarlo, A Chavez, SL Dietz, KM Esvelt, GM Church Nature biotechnology 33 (12), 1250-1255, 2015	402	2015
Cas9 gRNA engineering for genome editing, activation and repression S Kiani, A Chavez, M Tuttle, RN Hall, R Chari, D Ter-Ovanesyan, J Qian, ... Nature methods 12 (11), 1051-1054, 2015	379	2015
Multiple pathways for SARS-CoV-2 resistance to nirmatrelvir S Iketani, H Mohri, B Culbertson, SJ Hong, Y Duan, MI Luck, ... Nature 613 (7944), 558-564, 2023	325	2023
An Integrated Genome-wide CRISPRa Approach to Functionalize lncRNAs in Drug Resistance AC Bester, JD Lee, A Chavez, YR Lee, D Nachmani, S Vora, J Victor, ... Cell 173 (3), 649-664. e20, 2018	315	2018
Daisy-chain gene drives for the alteration of local populations C Noble, J Min, J Olejarz, J Buchthal, A Chavez, AL Smidler, ... Proceedings of the National Academy of Sciences 116 (17), 8275-8282, 2019	245	2019
sgRNA Scorer 2.0: A species-independent model to predict CRISPR/Cas9 activity R Chari, NC Yeo, A Chavez, GM Church ACS synthetic biology 6 (5), 902-904, 2017	240	2017
A CRISPR–Cas9-based gene drive platform for genetic interaction analysis in Candida albicans RS Shapiro, A Chavez, CBM Porter, M Hamblin, CS Kaas, JE DiCarlo, ... Nature microbiology 3 (1), 73-82, 2018	162	2018
Enhanced Bacterial Immunity and Mammalian Genome Editing via RNA-Polymerase-Mediated Dislodging of Cas9 from Double-Strand DNA Breaks R Clarke, R Heler, MS MacDougall, NC Yeo, A Chavez, M Regan, ... Molecular cell 71 (1), 42-55. e8, 2018	160	2018
Lead compounds for the development of SARS-CoV-2 3CL protease inhibitors S Iketani, F Forouhar, H Liu, SJ Hong, FY Lin, MS Nair, A Zask, Y Huang, ... Nature communications 12 (1), 2016, 2021	118	2021
CRISPR-based genomic tools for the manipulation of genetically intractable microorganisms RS Shapiro, A Chavez, JJ Collins Nature Reviews Microbiology 16 (6), 333-339, 2018	111	2018
High-throughput creation and functional profiling of DNA sequence variant libraries using CRISPR–Cas9 in yeast X Guo, A Chavez, A Tung, Y Chan, C Kaas, Y Yin, R Cecchi, SL Garnier, ... Nature biotechnology 36 (6), 540-546, 2018	104	2018
Molecular mechanisms of SARS-CoV-2 resistance to nirmatrelvir Y Duan, H Zhou, X Liu, S Iketani, M Lin, X Zhang, Q Bian, H Wang, H Sun, ... Nature 622 (7982), 376-382, 2023	102	2023
Rap1 relocalization contributes to the chromatin-mediated gene expression profile and pace of cell senescence JM Platt, P Ryvkin, JJ Wanat, G Donahue, MD Ricketts, SP Barrett, ... Genes & development 27 (12), 1406-1420, 2013	98	2013

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