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Tanya S. Freedman
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ZAP-70: an essential kinase in T-cell signaling
H Wang, TA Kadlecek, BB Au-Yeung, HE Sjolin Goodfellow, LY Hsu, ...
Cold Spring Harbor Perspect Biol 1, a002980, 2010
4592010
A Ras-induced conformational switch in the Ras activator Son of sevenless
TS Freedman, H Sondermann, GD Friedland, T Kortemme, D Bar-Sagi, ...
Proc Natl Acad Sci USA 103 (45), 16692-16697, 2006
1782006
STIM1, PKC-δ and RasGRP set a threshold for proapoptotic Erk signaling during B cell development
A Limnander, P Depeille, TS Freedman, J Liou, M Leitges, T Kurosaki, ...
Nat Immunol 12 (5), 425, 2011
1372011
Inhibition of the kinase Csk in thymocytes reveals a requirement for actin remodeling in the initiation of full TCR signaling
YX Tan, BN Manz, TS Freedman, C Zhang, KM Shokat, A Weiss
Nat Immunol 15 (2), 186-194, 2014
1082014
Structural analysis of the inactive state of the Escherichia coli DNA polymerase clamp-loader complex
SL Kazmirski, M Podobnik, TF Weitze, M O'Donnell, J Kuriyan
Proc Natl Acad Sci U S A 101 (48), 16750-5, 2004
752004
The Src-family kinase Lyn in immunoreceptor signaling
BF Brian IV, TS Freedman
Endocrinology, 2021
412021
Nucleotide-induced conformational changes in an isolated Escherichia coli DNA polymerase III clamp loader subunit
M Podobnik, TF Weitze, M O'Donnell, J Kuriyan
Structure 11 (3), 253-63, 2003
412003
Differences in flexibility underlie functional differences in the Ras activators son of sevenless and Ras guanine nucleotide releasing factor 1
TS Freedman, H Sondermann, O Kuchment, GD Friedland, T Kortemme, ...
Structure 17 (1), 41-53, 2009
392009
LynA regulates an inflammation-sensitive signaling checkpoint in macrophages
TS Freedman, YX Tan, KM Skrzypczynska, BN Manz, FV Sjaastad, ...
eLife 4, e09183, 2015
362015
Lessons of COVID-19: A roadmap for post-pandemic science
TS Freedman, MB Headley, N Serwas, M Ruhland, CA Castellanos, ...
J Exp Med 217 (9), e20201276, 2020
162020
Regulation of myeloid-cell activation
JT Greene, BF Brian IV, SE Senevirathne, TS Freedman
Curr Opin Immunol 73, 34-42, 2021
132021
Unique-region phosphorylation targets LynA for rapid degradation, tuning its expression and signaling in myeloid cells
BF Brian IV, AS Jolicoeur, CR Guerrero, MG Nunez, ZE Sychev, SA Hegre, ...
eLife 8, e46043, 2019
132019
Immunopharmacology and quantitative analysis of tyrosine kinase signaling
BF Brian IV, CR Guerrero, TS Freedman
Curr Protoc Immunol 130, e104, 2020
102020
A dominant function of LynB kinase in preventing autoimmunity
BF Brian IV, ML Sauer, JT Greene, SE Senevirathne, AJ Lindstedt, ...
Sci Adv 8, eabj5227, 2022
8*2022
SH3-domain mutations selectively disrupt Csk homodimerization or PTPN22 binding
BF Brian IV, FV Sjaastad, TS Freedman
Sci Rep 12, 5875, 2022
62022
Allosteric coupling asymmetry mediates paradoxical activation of BRAF by type II inhibitors
DM Rasmussen, MM Semonis, JT Greene, JM Muretta, AR Thompson, ...
eLife 13, RP95481, 2024
12024
ZBTB7A as a novel vulnerability in neuroendocrine prostate cancer
SY Bae, HE Bergom, A Day, JT Greene, TS Freedman, J Hwang, ...
Front Endocrinol 14, 403, 2023
12023
Enhanced IL-15-mediated NK cell activation and proliferation by an ADAM17 function-blocking antibody involves CD16A, CD137, and accessory cells
AW Matson, RH Hullsiek, KJ Dixon, AJ Lindstedt, RR Friess, SK Phung, ...
bioRxiv, 2024.05. 09.593347, 2024
2024
(Abstract) Lyn kinase regulates myeloid-cell responses to mammary tumors
JT Greene, BF Brian IV, A Bapat, TS Freedman
Cancer Immunology Research 11 (12_Supplement), PR02-PR02, 2023
2023
Primary infection with Zika virus provides one-way heterologous protection against Spondweni virus infection in rhesus macaques
AS Jaeger, CM Crooks, AM Weiler, MI Bliss, S Rybarczyk, A Richardson, ...
Science Advances 9 (26), eadg3444, 2023
2023
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