| Enantioselective, intermolecular benzylic C–H amination catalysed by an engineered iron-haem enzyme CK Prier, RK Zhang, AR Buller, S Brinkmann-Chen, FH Arnold Nature chemistry 9 (7), 629-634, 2017 | 392 | 2017 |
| A homozygous mutation in human PRICKLE1 causes an autosomal-recessive progressive myoclonus epilepsy-ataxia syndrome AG Bassuk, RH Wallace, A Buhr, AR Buller, Z Afawi, M Shimojo, S Miyata, ... The American Journal of Human Genetics 83 (5), 572-581, 2008 | 251 | 2008 |
| Directed evolution of the tryptophan synthase β-subunit for stand-alone function recapitulates allosteric activation AR Buller, S Brinkmann-Chen, DK Romney, M Herger, J Murciano-Calles, ... Proceedings of the National Academy of Sciences 112 (47), 14599-14604, 2015 | 184 | 2015 |
| Enzyme-controlled nitrogen-atom transfer enables regiodivergent C–H amination TK Hyster, CC Farwell, AR Buller, JA McIntosh, FH Arnold Journal of the American Chemical Society 136 (44), 15505-15508, 2014 | 181 | 2014 |
| Intrinsic evolutionary constraints on protease structure, enzyme acylation, and the identity of the catalytic triad AR Buller, CA Townsend Proceedings of the National Academy of Sciences 110 (8), E653-E661, 2013 | 175 | 2013 |
| Catalytic iron-carbene intermediate revealed in a cytochrome c carbene transferase RD Lewis, M Garcia-Borràs, MJ Chalkley, AR Buller, KN Houk, SBJ Kan, ... Proceedings of the National Academy of Sciences 115 (28), 7308-7313, 2018 | 126 | 2018 |
| Directed evolution mimics allosteric activation by stepwise tuning of the conformational ensemble AR Buller, P Van Roye, JKB Cahn, RA Scheele, M Herger, FH Arnold Journal of the American Chemical Society 140 (23), 7256-7266, 2018 | 101 | 2018 |
| Synthesis of β-branched tryptophan analogues using an engineered subunit of tryptophan synthase M Herger, P van Roye, DK Romney, S Brinkmann-Chen, AR Buller, ... Journal of the American Chemical Society 138 (27), 8388-8391, 2016 | 101 | 2016 |
| Consecutive radical S-adenosylmethionine methylations form the ethyl side chain in thienamycin biosynthesis DR Marous, EP Lloyd, AR Buller, KA Moshos, TL Grove, AJ Blaszczyk, ... Proceedings of the National Academy of Sciences 112 (33), 10354-10358, 2015 | 94 | 2015 |
| A panel of TrpB biocatalysts derived from tryptophan synthase through the transfer of mutations that mimic allosteric activation J Murciano‐Calles, DK Romney, S Brinkmann‐Chen, AR Buller, ... Angewandte Chemie International Edition 55 (38), 11577-11581, 2016 | 86 | 2016 |
| Engineered biosynthesis of β‐alkyl tryptophan analogues CE Boville, RA Scheele, P Koch, S Brinkmann‐Chen, AR Buller, ... Angewandte Chemie 130 (45), 14980-14984, 2018 | 70 | 2018 |
| Biocatalytic synthesis of non-standard amino acids by a decarboxylative aldol reaction JM Ellis, ME Campbell, P Kumar, EP Geunes, CA Bingman, AR Buller Nature catalysis 5 (2), 136-143, 2022 | 44 | 2022 |
| Structural adaptability facilitates histidine heme ligation in a cytochrome P450 JA McIntosh, T Heel, AR Buller, L Chio, FH Arnold Journal of the American Chemical Society 137 (43), 13861-13865, 2015 | 42 | 2015 |
| l-Threonine Transaldolase Activity Is Enabled by a Persistent Catalytic Intermediate P Kumar, A Meza, JM Ellis, GA Carlson, CA Bingman, AR Buller ACS chemical biology 16 (1), 86-95, 2020 | 41 | 2020 |
| Tryptophan synthase uses an atypical mechanism to achieve substrate specificity AR Buller, P van Roye, J Murciano-Calles, FH Arnold Biochemistry 55 (51), 7043-7046, 2016 | 37 | 2016 |
| Site-selective deuteration of amino acids through dual-protein catalysis TJ Doyon, AR Buller Journal of the American Chemical Society 144 (16), 7327-7336, 2022 | 34 | 2022 |
| Scalable and Selective β‐Hydroxy‐α‐Amino Acid Synthesis Catalyzed by Promiscuous l‐Threonine Transaldolase ObiH TJ Doyon, P Kumar, S Thein, M Kim, A Stitgen, AM Grieger, C Madigan, ... ChemBioChem 23 (2), e202100577, 2022 | 32 | 2022 |
| Facile in vitro biocatalytic production of diverse tryptamines AD McDonald, LJ Perkins, AR Buller ChemBioChem 20 (15), 1939-1944, 2019 | 30 | 2019 |
| Substrate multiplexed protein engineering facilitates promiscuous biocatalytic synthesis AD McDonald, PM Higgins, AR Buller Nature Communications 13 (1), 5242, 2022 | 29 | 2022 |
| Cofactor specificity motifs and the induced fit mechanism in class I ketol-acid reductoisomerases JKB Cahn, S Brinkmann-Chen, T Spatzal, JA Wiig, AR Buller, O Einsle, ... Biochemical Journal 468 (3), 475-484, 2015 | 28 | 2015 |
Frances ArnoldProfessor of chemical engineering, CaltechBestätigte E-Mail-Adresse bei cheme.caltech.edu
