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Ryan Phelan
Ryan Phelan
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Jahr
An externally tunable bacterial band-pass filter
T Sohka, RA Heins, RM Phelan, JM Greisler, CA Townsend, M Ostermeier
Proceedings of the National Academy of Sciences 106 (25), 10135-10140, 2009
2062009
Engineering Terpene Biosynthesis in Streptomyces for Production of the Advanced Biofuel Precursor Bisabolene
RM Phelan, ON Sekurova, JD Keasling, SB Zotchev
ACS Synthetic Biology 4 (4), 393-399, 2015
782015
Development of Next Generation Synthetic Biology Tools for Use in Streptomyces venezuelae
RM Phelan, D Sachs, SJ Petkiewicz, JF Barajas, JM Blake-Hedges, ...
ACS synthetic biology 6 (1), 159-166, 2017
762017
Comprehensive structural and biochemical analysis of the terminal myxalamid reductase domain for the engineered production of primary alcohols
JF Barajas, RM Phelan, AJ Schaub, JT Kliewer, PJ Kelly, DR Jackson, ...
Chemistry & biology 22 (8), 1018-1029, 2015
622015
Production of Odd-Carbon Dicarboxylic Acids in Escherichia coli Using an Engineered Biotin–Fatty Acid Biosynthetic Pathway
RW Haushalter, RM Phelan, KM Hoh, C Su, G Wang, EEK Baidoo, ...
Journal of the American Chemical Society 139 (13), 4615-4618, 2017
402017
Mechanistic insights into the bifunctional non-heme iron oxygenase carbapenem synthase by active site saturation mutagenesis
RM Phelan, CA Townsend
Journal of the American Chemical Society 135 (20), 7496-7502, 2013
402013
Definition of the Common and Divergent Steps in Carbapenem β‐Lactam Antibiotic Biosynthesis
MJ Bodner, R Li, RM Phelan, MF Freeman, KA Moshos, EP Lloyd, ...
ChemBioChem 12 (14), 2159-2165, 2011
372011
Design and synthesis of a β-lactamase activated 5-fluorouracil prodrug
RM Phelan, M Ostermeier, CA Townsend
Bioorganic & medicinal chemistry letters 19 (4), 1261-1263, 2009
372009
Non-heme iron oxygenases generate natural structural diversity in carbapenem antibiotics
MJ Bodner, RM Phelan, MF Freeman, R Li, CA Townsend
Journal of the American Chemical Society 132 (1), 12-13, 2010
352010
In vitro Characterization of Phenylacetate Decarboxylase, a Novel Enzyme Catalyzing Toluene Biosynthesis in an Anaerobic Microbial Community
K Zargar, R Saville, RM Phelan, SG Tringe, CJ Petzold, JD Keasling, ...
Scientific reports 6 (1), 31362, 2016
342016
Divergent Mechanistic Routes for the Formation of gem‐Dimethyl Groups in the Biosynthesis of Complex Polyketides
S Poust, RM Phelan, K Deng, L Katz, CJ Petzold, JD Keasling
Angewandte Chemie International Edition 54 (8), 2370-2373, 2015
332015
A catalytic asymmetric route to carbapenems
MJ Bodner, RM Phelan, CA Townsend
Organic letters 11 (16), 3606-3609, 2009
322009
A high-throughput screen for the engineered production of β-lactam antibiotics
RM Phelan, BJ DiPardo, CA Townsend
ACS Chemical Biology 7 (5), 835-840, 2012
192012
Development of scalable processes with underutilized biocatalyst classes
RM Phelan, MJ Abrahamson, JTC Brown, RK Zhang, CR Zwick III
Organic Process Research & Development 26 (7), 1944-1959, 2022
42022
Solid, Noncovalent Formulation of Biocatalysts for Rapid and Accurate Submilligram Dosing to Microtiter Plates
JTC Brown, NP Tu, RM Phelan
Organic Process Research & Development 25 (2), 337-341, 2021
32021
Discovery of Small Molecule Interleukin 17A Inhibitors with Novel Binding Mode and Stoichiometry: Optimization of DNA-Encoded Chemical Library Hits to In Vivo Active Compounds
AL Ramos, ER Goedken, KE Frank, MA Argiriadi, S Bazzaz, Z Bian, ...
Journal of Medicinal Chemistry, 2024
2024
Comparison of Diverse Amine Donors for Use in the High-Throughput Screening of Amine Transaminases
JTC Brown, RM Phelan
Organic Process Research & Development 27 (7), 1293-1299, 2023
2023
Characterization of an ECF56-family sigma factor from Streptomyces venezuelae reveals a highly conserved regulome
MG Thompson, A Zargar, P Cruz-Morales, T De Rond, S Chang, ...
bioRxiv, 2020.01. 30.927608, 2020
2020
Method for late introduction of the (8R) hydroxyl group carbapenem β-lactam antibiotic synthesis
CA Townsend, MJ Bodner, RM Phelan, MF Freeman
US Patent 9,458,479, 2016
2016
Method for late introduction of the (8R)-hydroxyl group carbapenem β-lactam antibiotic synthesis
CA Townsend, MJ Bodner, RM Phelan, MF Freeman
US Patent 9,139,588, 2015
2015
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