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Michael Downey
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A phosphatase complex that dephosphorylates γH2AX regulates DNA damage checkpoint recovery
MC Keogh, JA Kim, M Downey, J Fillingham, D Chowdhury, JC Harrison, ...
Nature 439 (7075), 497-501, 2006
6202006
A genome-wide screen identifies the evolutionarily conserved KEOPS complex as a telomere regulator
M Downey, R Houlsworth, L Maringele, A Rollie, M Brehme, S Galicia, ...
Cell 124 (6), 1155-1168, 2006
2102006
Atomic structure of the KEOPS complex: an ancient protein kinase-containing molecular machine
DYL Mao, D Neculai, M Downey, S Orlicky, YZ Haffani, DF Ceccarelli, ...
Molecular cell 32 (2), 259-275, 2008
1072008
A Genomewide Suppressor and Enhancer Analysis of cdc13-1 Reveals Varied Cellular Processes Influencing Telomere Capping in Saccharomyces cerevisiae
SG Addinall, M Downey, M Yu, MK Zubko, J Dewar, A Leake, J Hallinan, ...
Genetics 180 (4), 2251-2266, 2008
1032008
γH2AX as a checkpoint maintenance signal
M Downey, D Durocher
Cell Cycle 5 (13), 1376-1381, 2006
822006
Acetylome profiling reveals overlap in the regulation of diverse processes by sirtuins, gcn5, and esa1
M Downey, JR Johnson, NE Davey, BW Newton, TL Johnson, S Galaang, ...
Molecular & Cellular Proteomics 14 (1), 162-176, 2015
782015
A screen for candidate targets of lysine polyphosphorylation uncovers a conserved network implicated in ribosome biogenesis
A Bentley-DeSousa, C Holinier, H Moteshareie, YC Tseng, S Kajjo, ...
Cell reports 22 (13), 3427-3439, 2018
662018
Gcn5 and sirtuins regulate acetylation of the ribosomal protein transcription factor Ifh1
M Downey, B Knight, AA Vashisht, CA Seller, JA Wohlschlegel, D Shore, ...
Current biology 23 (17), 1638-1648, 2013
522013
Polymerase stalling during replication, transcription and translation
ER Edenberg, M Downey, D Toczyski
Current Biology 24 (10), R445-R452, 2014
472014
Chromatin and DNA repair: the benefits of relaxation
M Downey, D Durocher
Nature Cell Biology 8 (1), 9-10, 2006
472006
Distinct parts of minichromosome maintenance protein 2 associate with histone H3/H4 and RNA polymerase II holoenzyme
L Holland, M Downey, X Song, L Gauthier, P Bell‐Rogers, K Yankulov
European journal of biochemistry 269 (21), 5192-5202, 2002
442002
Proteomic analysis of SRm160-containing complexes reveals a conserved association with cohesin
S McCracken, D Longman, E Marcon, P Moens, M Downey, JA Nickerson, ...
Journal of Biological Chemistry 280 (51), 42227-42236, 2005
392005
A broad respone to intracellular long-chain polyphosphate in human cells
E Bondy-Chorney, I Abramchuk, R Nasser, C Holinier, A Denoncourt, ...
Cell Reports 33 (4), 108318, 2020
382020
Heart failure drug proscillaridin A targets MYC overexpressing leukemia through global loss of lysine acetylation
EM Da Costa, G Armaos, G McInnes, A Beaudry, G Moquin-Beaudry, ...
Journal of Experimental & Clinical Cancer Research 38, 1-14, 2019
342019
SIRT3 controls brown fat thermogenesis by deacetylation regulation of pathways upstream of UCP1
R Sebaa, J Johnson, C Pileggi, M Norgren, J Xuan, Y Sai, Q Tong, ...
Molecular Metabolism 25, 35-49, 2019
342019
Non-histone protein acetylation by the evolutionarily conserved GCN5 and PCAF acetyltransferases
M Downey
Biochimica et Biophysica Acta (BBA)-Gene Regulatory Mechanisms 1864 (2), 194608, 2021
312021
Model systems for studying polyphosphate biology: a focus on microorganisms
A Denoncourt, M Downey
Current Genetics, 1-16, 2021
302021
Nonhistone targets of KAT2A and KAT2B implicated in cancer biology
E Bondy-Chorney, A Denoncourt, Y Sai, M Downey
Biochemistry and Cell Biology 97 (1), 30-45, 2019
302019
Hmgcs2-mediated ketogenesis modulates high-fat diet-induced hepatosteatosis
S Asif, RY Kim, T Fatica, J Sim, X Zhao, Y Oh, A Denoncourt, AC Cheung, ...
Molecular metabolism 61, 101494, 2022
292022
Building a KATalogue of acetyllysine targeting and function
M Downey, K Baetz
Briefings in functional genomics 15 (2), 109-118, 2016
232016
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