Follow
Alexander L. Nielsen
Alexander L. Nielsen
Senior Scientist, Novo Nordisk
Verified email at novonordisk.com
Title
Cited by
Cited by
Year
Class I histone deacetylases (HDAC1–3) are histone lysine delactylases
C Moreno-Yruela, D Zhang, W Wei, M Bæk, W Liu, J Gao, D Danková, ...
Science advances 8 (3), eabi6696, 2022
1522022
Recent achievements in developing selective Gq inhibitors
H Zhang, AL Nielsen, K Strømgaard
Medicinal research reviews 40 (1), 135-157, 2020
322020
Mechanism-based inhibitors of SIRT2: structure–activity relationship, X-ray structures, target engagement, regulation of α-tubulin acetylation and inhibition of breast cancer …
AL Nielsen, N Rajabi, N Kudo, K Lundø, C Moreno-Yruela, M Bæk, ...
RSC Chemical Biology 2 (2), 612-626, 2021
302021
Structure–activity relationship and conformational studies of the natural product cyclic depsipeptides YM-254890 and FR900359
H Zhang, AL Nielsen, MW Boesgaard, K Harpsøe, NL Daly, XF Xiong, ...
European journal of medicinal chemistry 156, 847-860, 2018
292018
Investigation of Carboxylic Acid Isosteres and Prodrugs for Inhibition of the Human SIRT5 Lysine Deacylase Enzyme
N Rajabi, TN Hansen, AL Nielsen, HT Nguyen, M Bæk, JE Bolding, ...
Angewandte Chemie 134 (22), e202115805, 2022
172022
Dethioacylation by sirtuins 1–3: considerations for drug design using mechanism-based sirtuin inhibition
N Rajabi, AL Nielsen, CA Olsen
ACS Medicinal Chemistry Letters 11 (10), 1886-1892, 2020
172020
Catch and anchor approach to combat both toxicity and longevity of botulinum toxin A
L Lin, ME Olson, T Sugane, LD Turner, MA Tararina, AL Nielsen, ...
Journal of medicinal chemistry 63 (19), 11100-11120, 2020
162020
Neurotrophic effects of vascular endothelial growth factor B and novel mimetic peptides on neurons from the central nervous system
O Dmytriyeva, A de Diego Ajenjo, K Lundø, H Hertz, KK Rasmussen, ...
ACS Chemical Neuroscience 11 (9), 1270-1282, 2020
142020
Cyclic peptides for drug development
X Ji, AL Nielsen, C Heinis
Angewandte Chemie International Edition 63 (3), e202308251, 2024
112024
Irreversible inhibition of BoNT/A protease: proximity-driven reactivity contingent upon a bifunctional approach
LD Turner, AL Nielsen, L Lin, S Pellett, T Sugane, ME Olson, EA Johnson, ...
RSC medicinal chemistry 12 (6), 960-969, 2021
102021
Mitochondria-targeted inhibitors of the human SIRT3 lysine deacetylase
KS Troelsen, M Bæk, AL Nielsen, AS Madsen, N Rajabi, CA Olsen
RSC Chemical Biology 2 (2), 627-635, 2021
102021
Solid-phase peptide synthesis on disulfide-linker resin followed by reductive release affords pure thiol-functionalized peptides
Z Bognar, GK Mothukuri, AL Nielsen, ML Merz, PMF Pânzar, C Heinis
Organic & Biomolecular Chemistry 20 (29), 5699-5703, 2022
82022
Use of crystallography and molecular modeling for the inhibition of the botulinum neurotoxin A protease
LD Turner, AL Nielsen, L Lin, AJ Campedelli, NR Silvaggi, JS Chen, ...
ACS Medicinal Chemistry Letters 12 (8), 1318-1324, 2021
32021
Substrates and Cyclic Peptide Inhibitors of the Oligonucleotide Activated Sirtuin 7
JE Bolding, AL Nielsen, I Jensen, TN Hansen, LA Ryberg, ST Jameson, ...
Angewandte Chemie International Edition, e202314597, 2023
22023
Transformation of a Metal Chelate into a “Catch and Anchor” Inhibitor of Botulinum A Protease
L Lin, EN Patel, AL Nielsen, LD Turner, WH Tepp, K Nguyen, S Pellett, ...
International Journal of Molecular Sciences 24 (5), 4303, 2023
22023
Synthetic fluorescent MYC probe: Inhibitor binding site elucidation and development of a high-throughput screening assay
RJ Shirey, JR Hart, BP Sridharan, SJ Novick, LD Turner, B Zhou, ...
Bioorganic & medicinal chemistry 42, 116246, 2021
22021
Finding the gas pedal on a slow sirtuin
AL Nielsen, CA Olsen
Journal of Biological Chemistry 295 (5), 1400-1401, 2020
12020
Solid‐phase peptide synthesis in 384‐well plates
M Schüttel, E Will, G Sangouard, A Zarda, S Habeshian, AL Nielsen, ...
Journal of Peptide Science, e3555, 2024
2024
Nanomole‐scale photochemical thiol‐ene chemistry for high‐throughput late‐stage diversification of peptide macrocycles
MD Nolan, M Schüttel, EM Scanlan, AL Nielsen
Peptide Science 116 (1), e24310, 2024
2024
De novo development of small cyclic peptides that are orally bioavailable
ML Merz, S Habeshian, B Li, JAGL David, AL Nielsen, X Ji, K Il Khwildy, ...
Nature Chemical Biology, 1-10, 2023
2023
The system can't perform the operation now. Try again later.
Articles 1–20