| Structural basis for selective inhibition of cyclooxygenase-2 by anti-inflammatory agents RG Kurumbail, AM Stevens, JK Gierse, JJ McDonald, RA Stegeman, ... Nature 384 (6610), 644-648, 1996 | 2342 | 1996 |
| A single amino acid difference between cyclooxygenase-1 (COX-1) and− 2 (COX-2) reverses the selectivity of COX-2 specific inhibitors JK Gierse, JJ McDonald, SD Hauser, SH Rangwala, CM Koboldt, ... Journal of Biological Chemistry 271 (26), 15810-15814, 1996 | 572 | 1996 |
| Expression and selective inhibition of the constitutive and inducible forms of human cyclo-oxygenase JK Gierse, SD Hauser, DP Creely, C Koboldt, SH Rangwala, PC Isakson, ... Biochemical Journal 305 (2), 479-484, 1995 | 514 | 1995 |
| Two novel heat shock genes encoding proteins produced in response to heterologous protein expression in Escherichia coli SP Allen, JO Polazzi, JK Gierse, AM Easton Journal of bacteriology 174 (21), 6938-6947, 1992 | 376 | 1992 |
| Kinetic basis for selective inhibition of cyclo-oxygenases JK Gierse, CM Koboldt, MC Walker, K Seibert, PC Isakson Biochemical Journal 339 (3), 607-614, 1999 | 335 | 1999 |
| Structural insights into the stereochemistry of the cyclooxygenase reaction JR Kiefer, JL Pawlitz, KT Moreland, RA Stegeman, WF Hood, JK Gierse, ... Nature 405 (6782), 97-101, 2000 | 291 | 2000 |
| A novel autotaxin inhibitor reduces lysophosphatidic acid levels in plasma and the site of inflammation J Gierse, A Thorarensen, K Beltey, E Bradshaw-Pierce, L Cortes-Burgos, ... Journal of Pharmacology and Experimental Therapeutics 334 (1), 310-317, 2010 | 264 | 2010 |
| Nitric oxide trapping of the tyrosyl radical of prostaglandin H synthase-2 leads to tyrosine iminoxyl radical and nitrotyrosine formation MR Gunther, LC Hsi, JF Curtis, JK Gierse, LJ Marnett, TE Eling, RP Mason Journal of Biological Chemistry 272 (27), 17086-17090, 1997 | 211 | 1997 |
| The bifunctional enzyme leukotriene-A4 hydrolase is an arginine aminopeptidase of high efficiency and specificity L Orning, JK Gierse, FA Fitzpatrick Journal of Biological Chemistry 269 (15), 11269-11273, 1994 | 132 | 1994 |
| A three-step kinetic mechanism for selective inhibition of cyclo-oxygenase-2 by diarylheterocyclic inhibitors MC WALKER, RG KURUMBAIL, JR KIEFER, KT MORELAND, ... Biochemical Journal 357 (3), 709-718, 2001 | 125 | 2001 |
| Inhibition of leukotriene A4 hydrolase/aminopeptidase by captopril. L Orning, G Krivi, G Bild, J Gierse, S Aykent, FA Fitzpatrick Journal of Biological Chemistry 266 (25), 16507-16511, 1991 | 107 | 1991 |
| Structure−Activity Relationship Studies on 1-[2-(4-Phenylphenoxy)ethyl]pyrrolidine (SC-22716), a Potent Inhibitor of Leukotriene A4 (LTA4) Hydrolase TD Penning, NS Chandrakumar, BB Chen, HY Chen, BN Desai, ... Journal of medicinal chemistry 43 (4), 721-735, 2000 | 105 | 2000 |
| Valdecoxib: assessment of cyclooxygenase-2 potency and selectivity JK Gierse, Y Zhang, WF Hood, MC Walker, JS Trigg, TJ Maziasz, ... Journal of Pharmacology and Experimental Therapeutics 312 (3), 1206-1212, 2005 | 104 | 2005 |
| Spatial requirements for 15-(R)-hydroxy-5Z, 8Z, 11Z, 13E-eicosatetraenoic acid synthesis within the cyclooxygenase active site of murine COX-2: why acetylated COX-1 does not … SW Rowlinson, BC Crews, DC Goodwin, C Schneider, JK Gierse, ... Journal of Biological Chemistry 275 (9), 6586-6591, 2000 | 101 | 2000 |
| Mutational analysis of the role of the distal histidine and glutamine residues of prostaglandin-endoperoxide synthase-2 in peroxidase catalysis, hydroperoxide reduction, and … LM Landino, BC Crews, JK Gierse, SD Hauser, LJ Marnett Journal of Biological Chemistry 272 (34), 21565-21574, 1997 | 98 | 1997 |
| Proteolytic processing of atriopeptin prohormone. ML Michener, JK Gierse, R Seetharam, KF Fok, PO Olins, MS Mai, ... Molecular pharmacology 30 (6), 552-557, 1986 | 98 | 1986 |
| Distinction of microsomal prostaglandin E synthase-1 (mPGES-1) inhibition from cyclooxygenase-2 inhibition in cells using a novel, selective mPGES-1 inhibitor G Mbalaviele, AM Pauley, AF Shaffer, BS Zweifel, S Mathialagan, ... Biochemical pharmacology 79 (10), 1445-1454, 2010 | 89 | 2010 |
| Mechanism-based inactivation of leukotriene A4 hydrolase/aminopeptidase by leukotriene A4. Mass spectrometric and kinetic characterization L Orning, J Gierse, K Duffin, G Bild, G Krivi, FA Fitzpatrick Journal of Biological Chemistry 267 (32), 22733-22739, 1992 | 84 | 1992 |
| Synthesis of potent leukotriene A4 hydrolase inhibitors. Identification of 3-[methyl [3-[4-(phenylmethyl) phenoxy] propyl] amino] propanoic acid TD Penning, MA Russell, BB Chen, HY Chen, CD Liang, MW Mahoney, ... Journal of medicinal chemistry 45 (16), 3482-3490, 2002 | 80 | 2002 |
| Characterization of celecoxib and valdecoxib binding to cyclooxygenase WF Hood, JK Gierse, PC Isakson, JR Kiefer, RG Kurumbail, K Seibert, ... Molecular pharmacology 63 (4), 870-877, 2003 | 77 | 2003 |
joseph mcdonaldOdyssey TherapeuticsVerified email at odysseytx.com
