Michael Reutlinger
Michael Reutlinger
F. Hoffmann-La Roche AG
Verified email at - Homepage
Cited by
Cited by
Discovery of Risdiplam, a Selective Survival of Motor Neuron-2 (SMN2) Gene Splicing Modifier for the Treatment of Spinal Muscular Atrophy (SMA)
H Ratni, M Ebeling, J Baird, S Bendels, J Bylund, KS Chen, N Denk, ...
Journal of Medicinal Chemistry 61 (15), 6501-6517, 2018
Chemically advanced template search (CATS) for scaffold-hopping and prospective target prediction for ‘orphan’molecules
M Reutlinger, CP Koch, D Reker, N Todoroff, P Schneider, T Rodrigues, ...
Molecular informatics 32 (2), 133, 2013
Revealing the macromolecular targets of complex natural products
D Reker, AM Perna, T Rodrigues, P Schneider, M Reutlinger, B Mönch, ...
Nature chemistry 6 (12), 1072-1078, 2014
Rationalizing tight ligand binding through cooperative interaction networks
B Kuhn, JE Fuchs, M Reutlinger, M Stahl, NR Taylor
Journal of chemical information and modeling 51 (12), 3180-3198, 2011
Voyages to the (un) known: adaptive design of bioactive compounds
G Schneider, M Hartenfeller, M Reutlinger, Y Tanrikulu, E Proschak, ...
Trends in biotechnology 27 (1), 18-26, 2009
Multi‐objective molecular de novo design by adaptive fragment prioritization
M Reutlinger, T Rodrigues, P Schneider, G Schneider
Angewandte Chemie International Edition 53 (16), 4244-4248, 2014
Combining on‐chip synthesis of a focused combinatorial library with computational target prediction reveals imidazopyridine GPCR ligands
M Reutlinger, T Rodrigues, P Schneider, G Schneider
Angewandte Chemie International Edition 53 (2), 582-585, 2014
Nonlinear dimensionality reduction and mapping of compound libraries for drug discovery
M Reutlinger, G Schneider
Journal of Molecular Graphics and Modelling 34, 108-117, 2012
Immunosuppressive Small Molecule Discovered by Structure‐Based Virtual Screening for Inhibitors of Protein–Protein Interactions
T Geppert, S Bauer, JA Hiss, E Conrad, M Reutlinger, P Schneider, ...
Angewandte Chemie International Edition 51 (1), 258-261, 2012
Neighborhood‐Preserving Visualization of Adaptive Structure–Activity Landscapes: Application to Drug Discovery
M Reutlinger, W Guba, RE Martin, AI Alanine, T Hoffmann, A Klenner, ...
Angewandte Chemie International Edition 50 (49), 11633-11636, 2011
Multidimensional De Novo Design Reveals 5‐HT2B Receptor‐Selective Ligands
T Rodrigues, N Hauser, D Reker, M Reutlinger, T Wunderlin, J Hamon, ...
Angewandte Chemie International Edition 54 (5), 1551-1555, 2015
Reaction-driven de novo design, synthesis and testing of potential type II kinase inhibitors
G Schneider, T Geppert, M Hartenfeller, F Reisen, A Klenner, ...
Future medicinal chemistry 3 (4), 415-424, 2011
Discovery of a novel class of survival motor neuron 2 splicing modifiers for the treatment of spinal muscular atrophy
E Pinard, L Green, M Reutlinger, M Weetall, NA Naryshkin, J Baird, ...
Journal of Medicinal Chemistry 60 (10), 4444-4457, 2017
Machine learning estimates of natural product conformational energies
M Rupp, MR Bauer, R Wilcken, A Lange, M Reutlinger, FM Boeckler, ...
PLoS computational biology 10 (1), e1003400, 2014
Drugs by numbers: reaction‐driven de novo design of potent and selective anticancer leads
B Spänkuch, S Keppner, L Lange, T Rodrigues, H Zettl, CP Koch, ...
Angewandte Chemie International Edition 52 (17), 4676-4681, 2013
Understanding molecular drivers of melanin binding to support rational design of small molecule ophthalmic drugs
P Jakubiak, M Reutlinger, P Mattei, F Schuler, A Urtti, R Alvarez-Sánchez
Journal of medicinal chemistry 61 (22), 10106-10115, 2018
Exhaustive proteome mining for functional MHC-I ligands
CP Koch, AM Perna, S Weissmüller, S Bauer, M Pillong, RB Baleeiro, ...
ACS chemical biology 8 (9), 1876-1881, 2013
Combinatorial chemistry by ant colony optimization
JA Hiss, M Reutlinger, CP Koch, AM Perna, P Schneider, T Rodrigues, ...
Future medicinal chemistry 6 (3), 267-280, 2014
Target profile prediction and practical evaluation of a biginelli-type dihydropyrimidine compound library
P Schneider, K Stutz, L Kasper, S Haller, M Reutlinger, F Reisen, ...
Pharmaceuticals 4 (9), 1236-1247, 2011
Kombination von On‐Chip‐Synthese einer fokussierten kombinatorischen Bibliothek mit computergestützter Vorhersage der biologischen Aktivität enthüllt Imidazopyridine als GPCR …
M Reutlinger, T Rodrigues, P Schneider, G Schneider
Angewandte Chemie 126 (2), 593-596, 2014
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