Thomas Lemmin
Thomas Lemmin
Scientific Researcher, ETH Zurich
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Trimeric HIV-1-Env structures define glycan shields from clades A, B, and G
GBE Stewart-Jones, C Soto, T Lemmin, GY Chuang, A Druz, R Kong, ...
Cell 165 (4), 813-826, 2016
Fusion peptide of HIV-1 as a site of vulnerability to neutralizing antibody
R Kong, K Xu, T Zhou, P Acharya, T Lemmin, K Liu, G Ozorowski, C Soto, ...
Science 352 (6287), 828-833, 2016
Palmitoylated calnexin is a key component of the ribosome–translocon complex
AKK Lakkaraju, L Abrami, T Lemmin, S Blaskovic, B Kunz, A Kihara, ...
The EMBO journal 31 (7), 1823-1835, 2012
Epitope-based vaccine design yields fusion peptide-directed antibodies that neutralize diverse strains of HIV-1
K Xu, P Acharya, R Kong, C Cheng, GY Chuang, K Liu, MK Louder, ...
Nature medicine 24 (6), 857-867, 2018
Structures of HIV-1 Env V1V2 with broadly neutralizing antibodies reveal commonalities that enable vaccine design
J Gorman, C Soto, MM Yang, TM Davenport, M Guttman, RT Bailer, ...
Nature structural & molecular biology 23 (1), 81, 2016
Quantification of the impact of the HIV-1-glycan shield on antibody elicitation
T Zhou, NA Doria-Rose, C Cheng, GBE Stewart-Jones, GY Chuang, ...
Cell reports 19 (4), 719-732, 2017
Critical roles of isoleucine-364 and adjacent residues in a hydrophobic gate control of phospholipid transport by the mammalian P4-ATPase ATP8A2
AL Vestergaard, JA Coleman, T Lemmin, SA Mikkelsen, LL Molday, ...
Proceedings of the National Academy of Sciences 111 (14), E1334-E1343, 2014
Alzheimer’s disease mutations in APP but not γ-secretase modulators affect epsilon-cleavage-dependent AICD production
M Dimitrov, JR Alattia, T Lemmin, R Lehal, A Fligier, J Houacine, ...
Nature communications 4 (1), 1-10, 2013
Structural heterogeneity and intersubject variability of Aβ in familial and sporadic Alzheimer’s disease
C Condello, T Lemmin, J Stöhr, M Nick, Y Wu, AM Maxwell, JC Watts, ...
Proceedings of the National Academy of Sciences 115 (4), E782-E791, 2018
De novo design of a hyperstable non-natural protein–ligand complex with sub-Å accuracy
NF Polizzi, Y Wu, T Lemmin, AM Maxwell, SQ Zhang, J Rawson, ...
Nature chemistry 9 (12), 1157, 2017
Designed metalloprotein stabilizes a semiquinone radical
G Ulas, T Lemmin, Y Wu, GT Gassner, WF DeGrado
Nature chemistry 8 (4), 354-359, 2016
Structural polymorphism of Alzheimer’s β-amyloid fibrils as controlled by an E22 switch: A solid-state NMR study
MR Elkins, T Wang, M Nick, H Jo, T Lemmin, SB Prusiner, WF DeGrado, ...
Journal of the American Chemical Society 138 (31), 9840-9852, 2016
Assembly of the transmembrane domain of E. coli PhoQ histidine kinase: implications for signal transduction from molecular simulations
T Lemmin, CS Soto, G Clinthorne, WF DeGrado, M Dal Peraro
PLoS Comput Biol 9 (1), e1002878, 2013
A 31-residue peptide induces aggregation of tau's microtubule-binding region in cells
J Stöhr, H Wu, M Nick, Y Wu, M Bhate, C Condello, N Johnson, J Rodgers, ...
Nature chemistry 9 (9), 874-881, 2017
A coiled coil switch mediates cold sensing by the thermosensory protein DesK
E Saita, LA Abriata, YT Tsai, F Trajtenberg, T Lemmin, A Buschiazzo, ...
Molecular microbiology 98 (2), 258-271, 2015
De novo design of covalently constrained mesosize protein scaffolds with unique tertiary structures
B Dang, H Wu, VK Mulligan, M Mravic, Y Wu, T Lemmin, A Ford, DA Silva, ...
Proceedings of the National Academy of Sciences 114 (41), 10852-10857, 2017
XFEL structures of the influenza M2 proton channel: Room temperature water networks and insights into proton conduction
JL Thomaston, RA Woldeyes, T Nakane, A Yamashita, T Tanaka, ...
Proceedings of the National Academy of Sciences 114 (51), 13357-13362, 2017
Perturbations of the straight transmembrane α-helical structure of the amyloid precursor protein affect its processing by γ-secretase
T Lemmin, M Dimitrov, PC Fraering, M Dal Peraro
Journal of Biological Chemistry 289 (10), 6763-6774, 2014
Microsecond dynamics and network analysis of the HIV-1 SOSIP Env trimer reveal collective behavior and conserved microdomains of the glycan shield
T Lemmin, C Soto, J Stuckey, PD Kwong
Structure 25 (10), 1631-1639. e2, 2017
Cardiolipin models for molecular simulations of bacterial and mitochondrial membranes
T Lemmin, C Bovigny, D Lançon, M Dal Peraro
Journal of chemical theory and computation 9 (1), 670-678, 2013
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