Kenzie MacIsaac
Kenzie MacIsaac
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Transcriptional regulatory code of a eukaryotic genome
CT Harbison, DB Gordon, TI Lee, NJ Rinaldi, KD Macisaac, TW Danford, ...
Nature 431 (7004), 99-104, 2004
Foxp3 occupancy and regulation of key target genes during T-cell stimulation
A Marson, K Kretschmer, GM Frampton, ES Jacobsen, JK Polansky, ...
Nature 445 (7130), 931-935, 2007
An improved map of conserved regulatory sites for Saccharomyces cerevisiae
KD MacIsaac, T Wang, DB Gordon, DK Gifford, GD Stormo, E Fraenkel
BMC bioinformatics 7 (1), 1-14, 2006
Tissue-specific transcriptional regulation has diverged significantly between human and mouse
DT Odom, RD Dowell, ES Jacobsen, W Gordon, TW Danford, ...
Nature genetics 39 (6), 730-732, 2007
A quantitative atlas of polyadenylation in five mammals
A Derti, P Garrett-Engele, KD MacIsaac, RC Stevens, S Sriram, R Chen, ...
Genome research 22 (6), 1173-1183, 2012
Practical strategies for discovering regulatory DNA sequence motifs
KD MacIsaac, E Fraenkel
PLoS computational biology 2 (4), e36, 2006
Tumor-derived IFN triggers chronic pathway agonism and sensitivity to ADAR loss
H Liu, J Golji, LK Brodeur, FS Chung, JT Chen, RS deBeaumont, ...
Nature medicine 25 (1), 95-102, 2019
Genomic characterization of Wilms' tumor suppressor 1 targets in nephron progenitor cells during kidney development
S Hartwig, J Ho, P Pandey, K MacIsaac, M Taglienti, M Xiang, G Alterovitz, ...
Development 137 (7), 1189-1203, 2010
High-resolution computational models of genome binding events
Y Qi, A Rolfe, KD MacIsaac, GK Gerber, D Pokholok, J Zeitlinger, ...
Nature biotechnology 24 (8), 963-970, 2006
FAP Delineates Heterogeneous and Functionally Divergent Stromal Cells in Immune-Excluded Breast TumorsFAP Delineates Divergent Stromal Cells in Breast Tumors
V Cremasco, JL Astarita, AL Grauel, S Keerthivasan, K MacIsaac, ...
Cancer immunology research 6 (12), 1472-1485, 2018
A hypothesis-based approach for identifying the binding specificity of regulatory proteins from chromatin immunoprecipitation data
KD MacIsaac, DB Gordon, L Nekludova, DT Odom, J Schreiber, ...
Bioinformatics 22 (4), 423-429, 2006
Genomic Analysis of Nasopharyngeal Carcinoma Reveals TME-Based SubtypesGenomic Subtypes of Nasopharyngeal Carcinoma
L Zhang, KD MacIsaac, T Zhou, PY Huang, C Xin, JR Dobson, K Yu, ...
Molecular Cancer Research 15 (12), 1722-1732, 2017
A quantitative model of transcriptional regulation reveals the influence of binding location on expression
KD MacIsaac, KA Lo, W Gordon, S Motola, T Mazor, E Fraenkel
PLoS computational biology 6 (4), e1000773, 2010
Phenotypic responses of differentiated asthmatic human airway epithelial cultures to rhinovirus
J Bai, SL Smock, GR Jackson Jr, KD MacIsaac, Y Huang, C Mankus, ...
PloS one 10 (2), e0118286, 2015
Characterization of Nigerian breast cancer reveals prevalent homologous recombination deficiency and aggressive molecular features
JJ Pitt, M Riester, Y Zheng, TF Yoshimatsu, A Sanni, O Oluwasola, ...
Nature communications 9 (1), 1-12, 2018
TGFβ-blockade uncovers stromal plasticity in tumors by revealing the existence of a subset of interferon-licensed fibroblasts
AL Grauel, B Nguyen, D Ruddy, T Laszewski, S Schwartz, J Chang, ...
Nature communications 11 (1), 1-17, 2020
Inhibition of RORγT skews TCRα gene rearrangement and limits T cell repertoire diversity
Y Guo, KD MacIsaac, Y Chen, RJ Miller, R Jain, B Joyce-Shaikh, ...
Cell reports 17 (12), 3206-3218, 2016
Pre-treatment whole blood gene expression is associated with 14-week response assessed by dynamic contrast enhanced magnetic resonance imaging in infliximab-treated rheumatoid …
KD MacIsaac, R Baumgartner, J Kang, A Loboda, C Peterfy, J DiCarlo, ...
PLoS One 9 (12), e113937, 2014
Stereochemical analysis of D-glucopyranosyl-sulfoxides via a combined NMR, molecular modeling and X-ray crystallographic approach
PH Buist, B Behrouzian, KD MacIsaac, S Cassel, P Rollin, A Imberty, ...
Tetrahedron: Asymmetry 10 (15), 2881-2889, 1999
Sequence analysis of chromatin immunoprecipitation data for transcription factors
KD MacIsaac, E Fraenkel
Computational Biology of Transcription Factor Binding, 179-193, 2010
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