| Enhanced preclinical antitumor activity of M7824, a bifunctional fusion protein simultaneously targeting PD-L1 and TGF-β Y Lan, D Zhang, C Xu, KW Hance, B Marelli, J Qi, H Yu, G Qin, A Sircar, ... Science translational medicine 10 (424), eaan5488, 2018 | 438 | 2018 |
| Toward high‐resolution homology modeling of antibody Fv regions and application to antibody–antigen docking A Sivasubramanian, A Sircar, S Chaudhury, JJ Gray Proteins: Structure, Function, and Bioinformatics 74 (2), 497-514, 2009 | 227 | 2009 |
| RosettaAntibody: antibody variable region homology modeling server A Sircar, ET Kim, JJ Gray Nucleic acids research 37 (suppl_2), W474-W479, 2009 | 198 | 2009 |
| SnugDock: paratope structural optimization during antibody-antigen docking compensates for errors in antibody homology models A Sircar, JJ Gray PloS computational biology 6 (1), e1000644, 2010 | 164 | 2010 |
| Structure-based design of supercharged, highly thermoresistant antibodies AE Miklos, C Kluwe, BS Der, S Pai, A Sircar, RA Hughes, M Berrondo, ... Chemistry & biology 19 (4), 449-455, 2012 | 159 | 2012 |
| Community-wide assessment of protein-interface modeling suggests improvements to design methodology SJ Fleishman, TA Whitehead, EM Strauch, JE Corn, S Qin, HX Zhou, ... Journal of molecular biology 414 (2), 289-302, 2011 | 156 | 2011 |
| Analysis and Modeling of the Variable Region of Camelid Single-Domain Antibodies A Sircar, KA Sanni, J Shi, JJ Gray The Journal of Immunology 186 (11), 6357-6367, 2011 | 99 | 2011 |
| A generalized approach to sampling backbone conformations with RosettaDock for CAPRI rounds 13–19 A Sircar, S Chaudhury, KP Kilambi, M Berrondo, JJ Gray Proteins: Structure, Function, and Bioinformatics 78 (15), 3115-3123, 2010 | 62 | 2010 |
| Incorporating biochemical information and backbone flexibility in RosettaDock for CAPRI rounds 6–12 S Chaudhury, A Sircar, A Sivasubramanian, M Berrondo, JJ Gray PROTEINS: Structure, Function, and Bioinformatics 69 (4), 793-800, 2007 | 55 | 2007 |
| SIRP-α immunoglobulin fusion proteins KM Lo, N Zizlsperger, A Sircar US Patent 11,021,694, 2021 | 39 | 2021 |
| Mechanism of polyubiquitin chain recognition by the human ubiquitin conjugating enzyme Ube2g2 WE Bocik, A Sircar, JJ Gray, JR Tolman Journal of biological chemistry 286 (5), 3981-3991, 2011 | 18 | 2011 |
| Enhanced preclinical antitumor activity of M7824, a bifunctional fusion protein simultaneously targeting PD-L1 and TGF-beta. Sci Transl Med. 2018 Y Lan, D Zhang, C Xu, KW Hance, B Marelli, J Qi, Y Huakui, G Qin, ... DOI: https://doi. org/10.1126/scitranslmed. aan5488, 0 | 18 | |
| Colocalized targeting of TGF-β and PD-L1 by bintrafusp alfa elicits distinct antitumor responses Y Lan, TL Yeung, H Huang, AA Wegener, S Saha, M Toister-Achituv, ... Journal for Immunotherapy of Cancer 10 (7), 2022 | 10 | 2022 |
| Preclinical evaluation and mechanistic characterization of M7824 (MSB0011359C), a novel bifunctional fusion protein targeting the PD-L1 and TGFβ pathways Y Lan, D Zhang, C Xu, B Marelli, J Qi, H Qi, G Qin, X Xu, H Wang, A Sircar, ... Cancer Research 77 (13_Supplement), 2615-2615, 2017 | 8 | 2017 |
| Methods for the homology modeling of antibody variable regions. A Sircar Methods in molecular biology (Clifton, NJ) 857, 301-311, 2012 | 8 | 2012 |
| IBC’s 22nd Annual Antibody Engineering and 9th Annual Antibody Therapeutics International Conferences and the 2011 Annual Meeting of The Antibody Society, December 5-8, 2011 … J Nilvebrant, DC Dunlop, A Sircar, T Wurch, E Falkowska, JM Reichert, ... mAbs 4 (2), 153-181, 2012 | 3 | 2012 |
| High-resolution homology modeling of antibody Fv regions using knowledge-based techniques, de novo loop modeling and docking A Sivasubramanian, A Sircar, S Chaudhury, JJ Gray Proteins 74, 497-514, 2008 | 3 | 2008 |
| Prepared sirp-alpha fusion proteins and pharmaceutical preparations containing them KM Lo, N Zizlsperger, A Sircar | | 2022 |
| Sirp-alpha immunoglobulin fusion proteins KM Lo, N Zizlsperger, A Sircar | | 2020 |
| Sirp-alpha immunoglobulin fusion proteins KM Lo, N ZIZLSPERGER, A SIRCAR | | 2016 |
Jeffrey J. GrayJohns Hopkins University, Chemical and Biomolecular Engineering / Program in Molecular BiophysicsVerified email at jhu.edu
